The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
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(2018/11/22)
Pd-catalyzed nucleophilic fluorination of aryl bromides
On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.
Lee, Hong Geun,Milner, Phillip J.,Buchwald, Stephen L.
supporting information
p. 3792 - 3795
(2014/04/03)
TRIAZOLOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS
This invention relates to triazolopyridyl compounds of the structural formula: [Formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
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Page/Page column 37
(2013/04/10)
Heterocyclic tetrazoles, a new class of lipolysis inhibitors.