- Linkers for the synthesis of multiple oligonucleotides in seriatim from a single support attachment
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A method for the synthesis of a plurality of oligonucleotides comprising the steps of (i) forming a first oligonucleotide on a first cleavable link attached to a solid support; (ii) attaching to the first oligonucleotide a cleavable linker moiety; (iii) forming a second oligonucleotide on the cleavable linker moiety; and (iv) cleaving the first cleavable link and the cleavable linker moiety to give a plurality of oligonucleotides; wherein the cleavable linker moiety is of the Formula (1): STR1 in which A1, A2 and E are as defined herein, and novel compounds which may be used in the operation of the method.
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- Agrochemical compositions and methods employing hymexazol and 1,2-benzisothiazolin-3-one
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A combination of 3-hydroxy-5-methylisoxazole with an antimicrobial agent has good agricultural fungicidal activity which lasts longer than 3-hydroxy-5-methylisoxazole alone. The dihydrate of the calcium salt of 3-hydroxy-5-methylisoxazole has advantages over the free 3-hydroxy-5-methylisoxazole, other salts and the anhydrous compound.
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- Difunctional and Hetercyclic Prducts from the Ozonolysis of Conjugated C5-C8 Cyclodienes
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Ozonolyses of the conjugated C5-C8 cyclodienes 1a-d in methanol, followed by reduction with DMS, have been examined.Monoozonolyses gave the corresponding unsaturated dialdehydes 2e as the primary products.In subsequent reactions, the dialdehydes 2e derived from the monoozonolyses of 1a, 1b, and 1c gave in high yields the heterocyclic compounds 7, 8k, and 9k, respectively.Diozonolyses of 1a-d gave the corresponding dialdehydes 3e as the primary products.In subsequent reactions, the dialdehydes 3e derived from 1b and 1c gave the heterocyclic compounds 8l and 9l, respectively.In addition, aldehydes 2e and 3e undervent partial acetalization reactions with methanol.
- Griesbaum, Karl,Jung, In Chang,Mertens, Henri
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p. 6024 - 6027
(2007/10/02)
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- CATALYTIC ISOMERIZATION OF ACETYLENIC SILYL ETHERS TO DIENOL SILYL ETHERS BY RUTHENIUM HYDRIDE COMPLEXES
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Acetylenic silyl ethers are converted catalytically to the corresponding conjugated dienol silyl ethers by ruthenium hydride complexes
- Hirai, Kenji,Suzuki, Hiroharu,Moro-oka, Yoshihiko,Ikawa, Tsuneo
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p. 3413 - 3416
(2007/10/02)
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