- Characterization of hydrazine derivative: Proposed decomposition mechanism and structure elucidation of decomposition compounds
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Decomposition of protected hydrazine diol (1) hemi-oxalate, a key intermediate of the potent indolocarbazole-based DNA topoisomerase I inhibitor (2), was investigated. Spectroscopic analysis revealed that the main decomposition compounds of the hydrazine
- Nemoto, Takayuki,Lazoura, Eliada,Nomoto, Takashi
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Read Online
- Selective catalytic oxidation of diglycerol
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The selective oxidation of α,α-diglycerol was studied using oxygen as a clean oxidant in the presence of a palladium/neocuproine complex. After optimization of the reaction parameters, the mono-oxidation product was obtained with 93% NMR yield (up to 76% isolated yield). The product was named “diglycerose” considering that it mainly exists as a cyclic hemi-ketal form.
- Wang, Huan,Vu, Nam Duc,Chen, Guo-Rong,Métay, Estelle,Duguet, Nicolas,Lemaire, Marc
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supporting information
p. 1154 - 1159
(2021/02/26)
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- Synthesis and catalytic evaluation of acidic carbons in the etherification of glycerol obtained from biodiesel production
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In this paper, the catalytic behaviour of carbonaceous system (Ccs) functionalized with –SO3H groups were studied in the etherification of refined (Gly) and crude glycerol (GlyC), with benzyl alcohol (BA). This Ccs was obtained by a synthetic method with low energetic cost in only 24 h. Its catalytic activity and selectivity were studied varying the catalyst percentage (2.5, 5 and 10 wt.%), the initial reactant molar ratio and temperature (between 80 and 120 °C). A very good catalytic performance was achieved (97 % conversion after 360 min of reaction), at 120 °C, Gly:BA = 3:1 and 10 wt.% of Ccs. The high activity can be attributed to high acid site density (6.4 mmol H+/g), that also allowed us to working at lower reaction temperature (100 °C) and with less catalyst concentration (2.5 wt.%), without observing significant loss in BA conversion. Monoether (ME1) was the major product of the reaction with 72 % selectivity. The material can be reused and still gives a notable conversion of BA (about 43 %) after three successive reuses. Finally, the Ccs was active and selective to the desired products in the etherification of crude glycerol (GlyC) derived of biodiesel industry. An important BA conversion (45 %) was obtained only reducing the water content of GlyC and without carrying out any other purification and/or neutralization treatment.
- Chiosso, María E.,Casella, Mónica L.,Merlo, Andrea B.
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p. 107 - 114
(2020/10/29)
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- Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides
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Following our findings on the anti-human immunodeficiency virus (HIV) activity of acyclovir (ACV) phosphate prodrugs, we herein report the ProTide approach applied to a series of acyclic nucleosides aimed at the identification of novel and selective antiv
- Derudas, Marco,Vanpouille, Christophe,Carta, Davide,Zicari, Sonia,Andrei, Graciela,Snoeck, Robert,Brancale, Andrea,Margolis, Leonid,Balzarini, Jan,McGuigan, Christopher
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p. 7876 - 7896
(2017/10/06)
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- The role of mesoporosity and Si/Al ratio in the catalytic etherification of glycerol with benzyl alcohol using ZSM-5 zeolites
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A comparative study of the influence of three different acid solids as catalysts (conventional zeolites Z15c with Si/Al = 19.5 and Z40c with Si/Al = 48.2, and a hierarchical zeolite Z40c-H with Si/Al = 50.0) for the etherification of glycerol with benzyl alcohol was performed. The catalytic activity and selectivity of these zeolites was elucidated at different catalyst contents. Three different ethers (3-benzyloxy-1,2-propanediol, which is a mono-benzyl-glycerol ether (MBG) and 1,3-dibenzyloxy-2-propanol, which is a di-benzyl-glycerol ether (DBG) and dibenzyl ether (DBz) were identified as the main products. MBG was the major product of the reaction catalyzed by the microporous Z15c zeolite with low Si/Al molar ratio, whereas DBG was formed in higher yield with the use of microporous Z40c and hierarchical Z40c-H zeolites, both of them having a similar high Si/Al molar ratio (≈50 MBG is a value-added product andit is obtained with good yield and selectivity when using the conventional zeolite Z15c as a catalyst.Under the best conditions tested, i.e., 25 mg of catalyst for 8 h at 120°C, a 62% of conversion was obtainedwithout the need of solvent, with an excellent 84% selectivity toward the MBG and no formation of DBz.
- Gonzalez-Arellano, Camino,Grau-Atienza, Aida,Serrano, Elena,Romero, Antonio A.,Garcia-Martinez, Javier,Luque, Rafael
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- Glycerol etherification with benzyl alcohol over sulfated zirconia catalysts
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Glycerol (GLY) etherification with benzyl alcohol (BA) was conducted with different zirconia-based heterogeneous acid catalysts, aiming to produce mono- (ME) and dibenzyl glycerol ethers (DE). Physicochemical properties of the prepared catalysts were obtained through XRD, SEM and adsorption of ammonia. The catalytic tests were performed at different temperatures (120-140°C) and initial reactant mass ratios (GLY:BA 1:1 and 2:1). The highest BA conversions were obtained with the catalyst having the highest sulfuric acid content (2S/ZrO2). An increase in the reaction temperature and the GLY:BA initial mass ratio led to an increase in the BA conversion. Two kinetic models (a potential and a hyperbolic approach) were proposed to describe the process performance, including not only reactants evolution with time, but also that of ME, DE and the undesired self-condensation product of BA (benzyl ether, BE). Kinetic parameters for each model were estimated by data fitting and both models were able to accurately describe the evolution of the system, in terms of reactants and product distribution as a function of time under the experimental conditions studied.
- Jaworski, María A.,Rodríguez Vega, Sergio,Siri, Guillermo J.,Casella, Mónica L.,Romero Salvador, Arturo,Santos López, Aurora
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- PROCESS FOR PREPARING PURINE DERIVATIVE
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A process for the preparation of famciclovir a compound of Formula (I) and its intermediates.
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Page/Page column 6
(2010/06/16)
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- New drug delivery nanosystem combining liposomal and dendrimeric technology (liposomal locked-in dendrimers) for cancer therapy
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Liposomal locked-in dendrimers (LLDs), the combination of liposomes and dendrimers in one formulation, represents a relatively new term in the drug carrier technology. LLDs undergone appropriate physicochemical investigation can merge the benefits of lipo
- Gardikis, Konstantinos,Hatziantoniou, Sophia,Bucos, Madalina,Fessas, Dimitrios,Signorelli, Marco,Felekis, Theodoros,Zervou, Maria,Screttas, Constantinos G.,Steele, Barry R.,Ionov, Maksim,Micha-Screttas, Maria,Klajnert, Barbara,Bryszewska, Maria,Demetzos, Costas
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scheme or table
p. 3561 - 3571
(2011/04/26)
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- Direct selective and controlled protection of multiple hydroxyl groups in polyols via iterative regeneration of stannylene acetals
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A direct selective protection (O-benzylation) of two or more hydroxyl groups in polyols displaying diverse structural patterns was made possible by the establishment of conditions that enable an efficient turnover for the Bu2Sn group, initially
- Simas, Alessandro B.C.,da Silva, Angelo A.T.,dos Santos Filho, Tarcizio J.,Barroso, Pedro T.W.
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supporting information; experimental part
p. 2744 - 2746
(2009/09/25)
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- AN IMPROVED PROCESS FOR PREPARING PURINE DERIVATIVE
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A process for the preparation of famciclovir a compound of Formula (I) and its intermediates.
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Page/Page column 11
(2009/01/23)
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- PREVENTION AND TREATMENT OF CANCER AND OTHER DISEASES
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Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of telomerase and reverse transcriptase, and are useful as antivirals, antibacterials and anticancer agents. Methods of treating or preventing cancers in patients involving administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases (RTs) expressed in cells of the patients are also disclosed. Method of using nucleoside analogs and other inhibitors of RTs in conjunction with DNA damaging agents such as genotoxic agents or radiation or photodynamic therapy or combinations these for the treatment of various cancers are also disclosed.
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Page/Page column 63
(2008/06/13)
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- Fluorescent phenylpolyene analogues of the ether phospholipid edelfosine for the selective labeling of cancer cells
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Edelfosine (ET-18-OCH3), a synthetic antitumor ether lipid, is taken up by malignant but not by normal cells, triggering apoptosis in a large variety of human tumor cells. The synthesis of the first fluorescent edelfosine analogue (6), with apo
- Quesada, Ernesto,Delgado, Javier,Gajate, Consuelo,Mollinedo, Faustino,Acu?a, A. Ulises,Amat-Guerri, Francisco
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p. 5333 - 5335
(2007/10/03)
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- Benzylation of alcohols by using bis[acetylacetonato]copper as catalyst
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Selective O-benzylation of primary hydroxy compounds has been achieved in the presence of bis[acetylacetonato]copper with benzyl chloride. We showed that bis[acetylacetonato]copper was very efficient in promoting the benzylation of primary aliphatic alcohols versus secondary aliphatic alcohols and phenolic hydroxy groups selectively.
- Sirkecioglu, Okan,Karliga, Bekir,Talinli, Naciye
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p. 8483 - 8485
(2007/10/03)
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- Original synthesis of linear, branched and cyclic oligoglycerol standards
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A variety of authentic standards of linear, branched and cyclic oligomers of glycerol, with well-defined structures and degrees of polymerisation from 2 to 5, have been efficiently synthesised. Linear oligomers were obtained by means of a convergent approach based on regioselective opening of bis(epoxides) with solketal; branched compounds were synthesised using oxidative cleavage of the corresponding anhydrohexitols as the key step. A 6-exo-trig halocyclisation reaction involving heteroatom-tethered unsaturated alcohols permitted an efficient synthesis of the precursors of selected cyclic dimers; larger cyclic oligomers were prepared by two one-pot Williamson reactions using a ditriflate derived from diglycerol. All these methodologies permitted further scaling up.
- Cassel, Stephanie,Debaig, Catherine,Benvegnu, Thierry,Chaimbault, Patrick,Lafosse, Michel,Plusquellec, Daniel,Rollin, Patrick
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p. 875 - 896
(2007/10/03)
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- Differential cleavage of arylmethyl ethers: Reactivity of 2,6-dimethoxybenzyl ethers
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CrCl2/LiI selectively cleave benzyl ethers and methoxy-substituted benzyl ethers (see scheme) in the order: C6H5CH2OR 6H4CH2OR 2C6H3CH2OR 2C6H3CH2OR. In contrast, C6H5CH2OR is more readily cleaved than 2,6-(MeO)2C6H3CH2OR during catalytic hydrogenolysis while 3,4-(MeO)2C6H3CH2OR is cleaved faster than 2,6-(MeO)2C6H3CH2OR with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).
- Falck,Barma,Baati, Rachid,Mioskowski, Charles
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p. 1281 - 1283
(2007/10/03)
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- Facile chelation-controlled reductive opening of methoxybenzylidene acetals with Bu3SnH and MgBr2. Regioselective protection strategy as MPM ethers
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A mild and efficient regioselective reductive opening of methoxybenzylidene acetals using a combination of Bu3SnH and MgBr2·OEt2, mainly via five-membered chelation intermediates is described. This reaction was applied to synthetic intermediates of myriaporon and tedanolide. (C) 2000 Elsevier Science Ltd.
- Zheng,Yamauchi,Dei,Kusaka,Matsui,Yonemitsu
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p. 6441 - 6445
(2007/10/03)
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- Synthesis and stereoselective aldol reaction of dihydroxyacetone derivatives
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Efficient synthetic methods for 1,3-di-O-benzyldihydroxyacetone (3) and 1,3-O-cyclohexylidenedihydroxyacetone (8) were developed. TiCl4-mediated aldol reaction of the silyl enol ether of 3 with aldehydes gave syn aldol products while the reacti
- Soo Kim, Kwan,Don Hong, Sung
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p. 5909 - 5913
(2007/10/03)
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- Enantioselective Syntheses of 2-Deoxyxylono-1,4-lactone and 2-Deoxyribono-1,4-lactone from 1,3-Dioxan-5-yl Diazoacetates
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1,3-Dioxan-5-yl diazoacetates are valuable substrates for highly diastereoselective and enantio-selective carbon-hydrogen insertion reactions. trans-2-(tert-Butyl)-1,3-dioxan-5-yl diazoacetate is a direct precursor to 2-deoxyribono-1,4-lactone in up to 81% ee, whereas cis-2-(tert-butyl)-1,3-dioxan-5-yl diazoacetate yields only the protected 2-deoxyxylono-1,4-lactone in up to 96% ee. However, trans-2-aryl-1,3-dioxan-5-yl diazoacetate (aryl = phenyl or 2-naphthyl) forms the precursor to 2-deoxyxylono-1,4-lactone in up to 95% ee but with the mirror image configuration of that produced from the trans-2-(tert-butyl) analogue. The catalysts that are most suitable for these carbon-hydrogen insertion reactions are chiral dirhodium(II) carboxamidates. 1,3-Dialkoxy-2-propyl diazoacetates give mainly 2-deoxyxylono-1,4-lactone derivatives (>90:10) with generally high enantiocontrol, but replacement of hydrogen at the 2-position of these 2-propyl diazoacetates led to a mixture of products.
- Doyle, Michael P.,Tedrow, Jason S.,Dyatkin, Alexey B.,Spaans, Coenraad J.,Ene, Doina G.
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p. 8907 - 8915
(2007/10/03)
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- ON THE MECHANISM OF BAKER'S YEAST-MEDIATED SYNTHESIS OF S-BENZYL (R)-THIOGLYCERATE. EXPERIMENTS WITH C3 PRECURSORS
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Deuterium labelling experiments with baker's yeast in the presence of dihydroxyacetone (DHA) and benzyl mercaptan allow the preparation of enantiomerically pure glycerol analogues, with different extents of label in different position.The mode of the enzymatic conversion of 3 into 1 is supported by 2H NMR studies onto the biotransformation products 9.
- Fronza, Giovanni,Fuganti, Claudio,Mele, Andrea,Pedrocchi-Fantoni, Giuseppe,Sarra, Antonella,Servi, Stefano
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p. 305 - 308
(2007/10/02)
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- SYNTHESIS OF 2-DEOXYXYLOLACTONE FROM GLYCEROL DERIVATIVES VIA HIGHLY ENANTIOSELECTIVE CARBON-HYDROGEN INSERTION REACTIONS
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diazodecomposition of 1,3-dialkoxy-2-propyl diazoacetates catalyzed by chiral dirhodium(II) carboxamides results in highly enantioselective and diastereoseelctive carbon-hydrogen insertion which forms 3,5-dialkyl 2-deoxyxylolactones in up to 98percent enantiomeric excess.
- Doyle, Michael P.,Dyatkin, Alexey B.,Tedrow, Jason S.
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p. 3853 - 3856
(2007/10/02)
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- Enhanced reactivity of secondary hydroxyl groups in the O-alkylation of carbohydrate-related primary-secondary vic-glycols. Regioselective 2-O-benzylation of 1,3:2,4-di-O-ethylidene-D-glucitol
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Partial O-alkylation of 1,3:2,4-di-O-ethylidene-D-glucitol (1a), 1,2-O-isopropylidene-3-O-methyl-α-D-glucofuranose (1b), and R-(+)-1-O-benzylglycerol (1c) with benzyl chloride in a KOH/DMSO system results in products of monoalkylation at the secondary (4a-c) and at the primary hydroxyl (2a-c) in ratios of over 95:5 (a), ca. 2:1 (b), and ca. 1:1 (c), whereas (+/-)propane-1,2-diol (1d) gives only the product of 1-O-benzylation (2d).A qualitatively similar result is observed upon O-alkylation of diols (1a-e) with 2-methoxyethanol tosylate.
- El'perina, E. A.,Struchkova, M. I.,Serkebaev, M. I.,Serebryakov, E. P.
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p. 744 - 750
(2007/10/02)
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- Nucleophilic Addition to Cyclic 1,2-Sulfites
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Addition of heteroatom nucleophiles has been shown to attack at either the C5- or the S-atom sites in 4-(benzyloxymethyl)-1,3-dioxa-2-thiolane 2-oxide.No C4-reactivity was observed.The regioselectivity depended on the type of nucleophile.
- Carlsen, Per H.,Aase, Kristin J.
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p. 617 - 619
(2007/10/02)
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- Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
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Compounds useful as antiviral agents are defined by the following formula: STR1 and the pharmaceutically acceptable acid addition salts thereof wherein R1 is hydrogen or --C(O)R7 wherein R7 is hydrogen, alkyl of one to nineteen carbon atoms, hydroxyalkyl of one to eight carbon atoms, alkoxyalkyl of two to nine carbon atoms, alkenyl of two to nineteen carbon atoms, phenyl, 1-adamantyl or 2-carboxyethyl and the pharmaceutically acceptable alkali metal salts thereof; R2 is --C(O)R7 wherein R7 is as defined above; R3 is hydrogen, halo, thio, lower alkylthio of one to six carbon atoms, azido, NR9 R10 wherein R9 and R10 are independently hydrogen or lower alkyl of one to six carbon atoms or --NHC(O)R8 wherein R8 is hydrogen, alkyl of one to nineteen carbon atoms or 1-adamantyl; and (a) R6 is hydrogen, halo, lower alkoxy of one to six carbon atoms, azido, thio, lower alkylthio of one to six carbon atoms, --NR9 R10 wherein R9 and R10 are as defined above or --NHC(O)R8 wherein R8 is as defined above and R4 together with R5 is a bond; or (b) R5 together with R6 is a keto group and R4 is hydrogen.
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- Polyols of a Cascade Type as a Water-Solubilizing Element of Carborane Derivatives for Boron Neutron Capture Therapy
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A practical method for the synthesis of polyols of a cascade type, as a water-solubilizing element of carborane derivatives for boron neutron capture therapy (BNCT), was developed.The carborane attached to the tetraol 6a was dissolved in water in a concentration of 5.44 M.
- Nemoto, Hisao,Wilson, J. Gerald,Nakamura, Hiroyuki,Yamamoto, Yoshinori
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- Synthesis and characterization of 2-0-β-lactosylglycerol, 1,2-di-0-β-lactosyl-(R,S)-glycerols, and 1,2,3-tri-0-β-lactosylglycerol
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The reaction of 2,3,6,2',3',4',6'-hepta-0-acetyl-α-lactosyl bromide (5) and 1,3-di-0-benzylglycerol in the presence of mercury(II) cyanide in benzene-nitromethane afforded 1,3-di-0-benzyl-2-0-(2,3,6,2',3',4',6'-hepta-0-acetyl-β- lactosyl)glycerol (70%), w
- Hronowski,Szarek,Hay,Krebs,Depew
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- Selective monoalkylation of acyclic diols by means of dibutyltin oxide and fluoride salts
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Fluoride anion was found to promote monoalkylation reaction of diols by the stannylene acetal method, and selective monoalkylation of various acyclic diols was accomplished in good yields under mild conditions by employing this new method. Functional groups such as carboxylic acid ester, carboxamide, carbamate, nitrile, alkyl chloride, and ether were not affected under the reaction conditions.
- Nagashima,Ohno
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p. 1972 - 1982
(2007/10/02)
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- Regioselective De-O-benzylation with Lewis Acids
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Simple and highly regioselective de-O-benzylations of poly-O-benzylated monosaccharides and polyols with Lewis acids (SnCl4 and TiCl4) were developed.Spectral studies on intermediates complexes showed that three appropriately situated metal chelating functional groups were necessary for the selective de-O-benzylation.
- Hori, Hiroshi,Nishida, Yoshihiro,Ohrui, Hiroshi,Meguro, Hiroshi
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p. 1346 - 1353
(2007/10/02)
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- The Chemistry of L-Ascorbic and D-Isoascorbic Acids. 2. R and S Glyceraldehydes from a Common Intermediate
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(R)- and (S)-glyceraldehyde and glycerol derivatives have been prepared from (2R,3S)-1,2-O-isopropylidenebutane-1,2,3,4-tetrol. (2R,3S)- and (2S,3S)-1,2-O-benzylidenebutane-1,2,3,4-tetrol have been prepared and cleaved to give (R)- and (S)-1,2-O-benzylideneglyceraldehydes and -glycerols.The conservation of chirality and conversion to PAF analogues are also demonstrated.
- Mikkilineni, Amarendra B.,Kumar, Praveen,Abushanab, Elie
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p. 6005 - 6009
(2007/10/02)
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- Effect of Acyclic Pyrimidines Related to 9-guanine on Herpesviruses
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A series of pyrimidines related to the potent antiherpetic agent 9-guanine (1, BW B759U), all containing the same acyclic chain, have been synthesized.Some of the compounds were derivatives of the naturally occuring bases, cytosine, uracil, and thymine; others included compounds in which the 5-position of the cytosine and uracil moieties were substituted by bromo, iodo, fluoro, methyl, and amino groups.Other variations of the cytosine derivatives were the 5-aza, 2-mercapto, 4-methylamino, 4-dimethylamino, and isocytosine congeners.A 4-aminopyrimidine adduct was also made.Antiviral testing showed that 1-cytosine (18, BW A1117U) was equivalent to the guanine analogue in the potency against human cytomegalovirus and Epstein Barr virus.Other compounds in the series were largely inactive in antiviral screening against the herpesviruses.
- Beauchamp, Lilia M.,Serling, Barbara L.,Kelsey, John E.,Biron, Karen K.,Collins, Peter,et al.
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p. 144 - 149
(2007/10/02)
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- TWO ACYCLIC ANALOGUES OF 2-β-D-RIBOFURANOSYL THIAZOLE-4-CARBOXAMIDE (TIAZOFURIN)
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Two different synthetic strategies have been elaborated for the synthesis of 2-thiazole-4-carboxamide (4) and 2-methyl>thiazole-4-carboxamide (5).
- Kovacs, Lajos,Herczegh, Pal,Batta, Gyula,Farkas, Istvan
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p. 947 - 960
(2007/10/02)
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- Process for preparing guanine derivatives
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1-Monophosphate esters, 1,3-bisphosphate esters and cyclic phosphate esters of 9-(1,3-dihydroxy-2-propoxymethyl)guanine are useful as antiviral agents.
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- Studies on Nucleosides: Part XIII - Synthesis and Antiviral Activity of Acyclic Analogues of Spongosine
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6-Amino-9--2-methoxypurine (9), 6-amino-2-ethoxy-9-purine (10) and 6-amino-9-(2-hydroxyethoxymethyl)-2-methoxypurine (17) have been synthesized.Condensation of 2,6-dichloropurine (4) with 2-O-chloromethyl-1,3-di-O-benzylglycerol (5) furnishes the protected acyclic nucleosides 8 (yield 50percent) and 7 (yield 7percent).Amination of 7 and 8 affords 6 and 13 respectively.Treatment of 13 with sodium methoxide and ethoxide gives 11 and 12 respectively.Deblocking of 11 and 12 with Pd-C/H2 finally produces 9 and 10 respectively.Condensation of 4 with 1-O-benzyl-2-O-chloromethylethanediol gives 19 (yield 55percent) and 15 (yield 5percent).Amination of 19 affords 18 which on treatment with sodium methoxide furnishes 16.Deblocking of 16 with Pd-C/H2 gives 17.Compounds 9, 10, 11, 13 and 17 in combination with interferon inducer, mycoviral ds RNA, exhibit 16, 0, 16, 40 and 40percent enhancement of protection respectively against the semliki forest virus in Swiss albino mice.
- Singh, P. K.,Saluja, Sunita,Pratap, Ram,George, C. X.,Bhakuni, D. S.
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p. 823 - 827
(2007/10/02)
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- 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine: A new potent and selective antiherpes agent
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The synthesis of a new acyclic analogue of deoxyguanosine, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG, 1) is described starting from epichlorohydrin via condensation of 2-O-(acetoxymethyl)-1,3-di-O-benzylglycerol (5) with N2,9-diacetylguanine (6). In vitro studies indicate that DHPG is a potent and broad-acting (herpes simplex virus types 1 and 2, cytomegalovirus, and Epstein-Barr virus) antiherpetic agent. In vivo studies indicate its lack of toxicity [LD50 (mice) = 1-2 g/kg, ip] and its superiority over acyclovir [oral ED50 = 7 (mg/kg)/day vs. 550 (mg/kg)/day in HSV-2 infected mice].
- Martin,Dvorak,Smee,Matthews,Verheyden
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p. 759 - 761
(2007/10/02)
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- A FACILE CLEAVAGE OF BENZYLIDENE ACETALS WITH DIISOBUTYLALUMINUM HYDRIDE
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Benzylidene acetals of 1,2- and 1,3-glycols are easily cleft by diisobutylaluminum hydride in a toluene solution at 0 deg C - room temperature to give the corresponding monobenzyl ethers of the glycols.In general the reaction proceeds excellently in regioselective manner depending on the stereochemical environment.
- Takano, Seiichi,Akiyama, Masashi,Sato, Seiji,Ogasawara, Kunio
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p. 1593 - 1596
(2007/10/02)
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- 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
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The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.
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- 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
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The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.
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- Veretherungen von Diolen, Triolen und Hydroxycarbonsaeurederivaten ueber Thallium(I)-alkoholate. Eine neue Variante der Williamson-Reaktion
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The etherifications listed in tables 1 and 2 are achieved by converting hydroxy-derivatives, which contain additional oxygen functions, into thallium(I) alkoxides with thallium ethoxide, and treatment with haloalkanes.The scope and limitations of the method are discussed.
- Kalinowski, Hans-Otto,Crass, Gerhard,Seebach, Dieter
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p. 477 - 487
(2007/10/02)
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