- Hunting for the Active Sites of Surface-Enhanced Raman Scattering: A New Strategy Based on Single Silver Particles
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Three major findings are reported here.First, a new technique based on lithographic modification with a scanning tunneling microscope (STM) has been developed for fabricating single Ag particles on atomically flat Au(111) surfaces.Second, surface-enhanced Raman scattering (SERS) from one isolated Ag particle has been observed and quantified for the first time.The enhancement factor due to one Ag particle of about 1 μm diameter is on the order of 1E4.This factor includes contributions from all forms of chemical enhancement, which are smaller than 1E2.Finally, strong evidence suggests the importance of clusters containing closely-spaced particles.Extra enhancement due to clusters of randomly distributed Ag particles is around 1E2.We believe that the extra enhancement is spatially localized near the gap sites between two particles in proximity.These gap sites from an important class of SERS-active sites.
- Xiao, Tong,Ye, Qi,Sun, Li
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Read Online
- Zero-Dimensional Hybrid Organic-Inorganic Indium Bromide with Blue Emission
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Low-dimensional hybrid organic-inorganic metal halides have received increased attention because of their outstanding optical and electronic properties. However, the most studied hybrid compounds contain lead and have long-term stability issues, which mus
- Fattal, Hadiah,Creason, Tielyr D.,Delzer, Cordell J.,Yangui, Aymen,Hayward, Jason P.,Ross, Bradley J.,Du, Mao-Hua,Glatzhofer, Daniel T.,Saparov, Bayrammurad
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p. 1045 - 1054
(2021/02/05)
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- Conjugated dyes carrying N, N-dialkylamino and ketone groups: One-component visible light Norrish type II photoinitiators
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This work presents new conjugated dyes carrying N, N-dialkylamino and ketone groups for using as one-component Norrish type II visible light photoinitiators. The novel dyes without ketone group were also synthesized to compose two-component visible light photoinitiators for comparisons. The target dyes show the remarkable absorption in visible light region. Photo-differential scanning calorimetry was employed to study visible light photoinitiating polymerization kinetics of methyl methacrylate by new one-component photoinitiators and two-component photoinitiators respectively. The results suggest that the one-component photoinitiators showed much more efficient photoinitiating polymerization of methyl methacrylate than the two-component photoinitiating systems under visible light irradiation. The molecular weight of visible light photopolymer produced by the new photoinitiators was determined. The visible light photoinitiating mechanism of the one-component photoinitiators was studied by absorption and emission spectra, electron spin resonance spectra and cyclic voltammograms analysis.
- Ding, Ge,Jing, Chuan,Qin, Xiaozhuan,Gong, Yulong,Zhang, Xueping,Zhang, Shengtao,Luo, Ziping,Li, Hongru,Gao, Fang
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p. 456 - 467
(2016/12/09)
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- Designing anti-inflammatory drugs from parasitic worms: A synthetic small molecule analogue of the acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis
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In spite of increasing evidence that parasitic worms may protect humans from developing allergic and autoimmune diseases and the continuing identification of defined helminth-derived immunomodulatory molecules, to date no new anti-inflammatory drugs have been developed from these organisms. We have approached this matter in a novel manner by synthesizing a library of drug-like small molecules based upon phosphorylcholine, the active moiety of the anti-inflammatory Acanthocheilonema viteae product, ES-62, which as an immunogenic protein is unsuitable for use as a drug. Following preliminary in vitro screening for inhibitory effects on relevant macrophage cytokine responses, a sulfone-containing phosphorylcholine analogue (11a) was selected for testing in an in vivo model of inflammation, collagen-induced arthritis (CIA). Testing revealed that 11a was as effective as ES-62 in protecting DBA/1 mice from developing CIA and mirrored its mechanism of action in downregulating the TLR/IL-1R transducer, MyD88. 11a is thus a novel prototype for anti-inflammatory drug development.
- Al-Riyami, Lamyaa,Pineda, Miguel A.,Rzepecka, Justyna,Huggan, Judith K.,Khalaf, Abedawn I.,Suckling, Colin J.,Scott, Fraser J.,Rodgers, David T.,Harnett, Margaret M.,Harnett, William
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supporting information
p. 9982 - 10002
(2014/01/17)
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- Titanium phthalocyanines with axial phenylenevinylenes
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The synthesis of soluble titanium(IV) phthalocyanines, axially substituted with phenylenevinylenes (PVs) (RxPcTiX), is described. The reaction of peripherally tetra- and octasubstituted (phthalocyaninato)titanium oxides (RxPcTiO) 1-3
- Lyubimtsev, Alexey,Misir, Mirac N.,Calvete, Mario,Hanack, Michael
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scheme or table
p. 3209 - 3214
(2009/05/11)
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- Dendrimers with peripheral stilbene chromophores
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Two types of dendritic nanoparticles were prepared, which contain (E)-stilbene chromophores in the terminal positions of the dendrons. The compounds showed a highly efficient photoreactivity in the course of which statistical CC bond formations led to a c
- Soomro, Shahid A.,Schulz, Andrea,Meier, Herbert
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p. 8089 - 8094
(2007/10/03)
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- Aromatic diketones
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Beta-diketones substituted by an aryl-aliphatic group in which the aliphatic chain is interrupted by a cyclic group, and useful as anti-viral agents, are prepared by interacting the appropriate aryl-aliphatic halide with an alkali metal salt of a beta-dik
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