- How Reaction Conditions May Influence the Regioselectivity in the Synthesis of 2,3-Dihydro-1,4-benzoxathiine Derivatives
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The exploration of different reaction conditions aiming to obtain both 2,3-dihydro-1,4-benzoxathiine-2-yl derivatives and 2,3-dihydro-1,4-benzoxathiine-3-yl ones is reported. The treatment of 1,2-mercaptophenol with an organic base and a specific 2-bromo acrylate results in a solvent- and substrate-dependent exclusive solvation of O- and S-anions, thus managing the regioselectivity.
- Casiraghi, Andrea,Valoti, Ermanno,Suigo, Lorenzo,Artasensi, Angelica,Sorvillo, Erica,Straniero, Valentina
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p. 13217 - 13227
(2018/10/24)
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- Reaction of amides of 2,3-dibromopropionic and 2-bromoacrylic acids with pyridine and triphenylphosphine
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By refluxing pyridine with 2,3-dibromopropionic acid amide in acetonitrile, amide of 3-bromo-2-pyridiniumbromidopropionic acid I was synthesized. The latter is inert toward the second molecule of pyridine under the used conditions. Compound I was found to
- Khachikyan,Tovmasyan,Indzhikyan
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experimental part
p. 759 - 761
(2009/09/26)
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