- Synthetic method of 3, 4-dihydro-2H-pyran [3, 2-b] pyridine
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The invention relates to a synthetic method of 3, 4-dihydro-2H-pyran [3, 2-b] pyridine, and mainly solves the technical problems that according to an existing synthetic method, raw materials are not easily acquired, reaction steps are long, palladium catalysis hydrogenation and debenzylation are achieved by the aid of precious metal palladium, and precious metal palladium is difficultly recycled.The technical scheme includes a synthetic method of the 3, 4-dihydro-2H-pyran [3, 2-b] pyridine. The synthetic method is characterized by including the steps: firstly, adding iodine into sodium carbonate solution with 3-pyridone to obtain a compound 1; secondly, reacting the compound 1 with 1, 3-dibromopropane under presence of alkali compounds, and stirring mixture at the indoor temperature overnight to obtain a compound 2; thirdly, reacting the compound 2 with n-butyllithium in tetrahydrofuran at the lower temperature to obtain a target compound 3, 4 dihydro-2H-pyran [3, 2-b] pyridine. The pyridine is provided with important framework structures of synthetic drugs.
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Paragraph 0013; 0014; 0015
(2018/03/25)
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- A mild catalytic system for radical conjugate addition of nitrogen heterocycles
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The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.
- Aycock,Wang,Jui
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p. 3121 - 3125
(2017/04/04)
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- AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE
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The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
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- AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE
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The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
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