- RETRACTED ARTICLE: Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases
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A series of thiochromeno[2,3-c]quinolin-12-one derivatives with various substitutions were synthesized and evaluated as topoisomerase (Topo) inhibitors. Six (8, 10, 12, 14, 19, and 26) of 23 compounds showed strong inhibitory activities against Topo-media
- Lee, Jiann-Fong,Chang, Ting-Yu,Liu, Zheng-Fang,Lee, Nian-Zhe,Yeh, Yen-Hsiu,Chen, Yi-Song,Chen, Tsung-Chih,Chou, Hao-Syun,Li, Tsai-Kun,Lee, Sung-Bau,Lin, Mei-Hsiang
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- FMS-LIKE TYROSINE KINASE INHIBITORS
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The present invention relates to Fms-like tyrosine kinase (FLT3) inhibitors. The present invention provides novel 4-quinolinone derivatives used as FLT3 inhibitors and for treatment and/or prevention of tumors.
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Page/Page column 25; 29; 57
(2020/03/31)
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- ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
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Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.
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Page/Page column 53
(2008/06/13)
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- KINETICS AND MECHANISM OF OXIDATION OF (ARYLTHIO)ACETIC ACIDS BY PYRIDINIUM HYDROBROMIDE PERBROMIDE
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Oxidation of several monosubstituted (phenylthio)acetic acids (PTAA) by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid.The reaction is first order with respect to PHPB.Michaelis-Menten type kinetics are observed with respect to (arylthio)acetic acid.The effect of solvent composition indicates that the transition state is more polar than the reactants.The formation constants of the intermediate substrate-PHPB complexes and the rates of their decomposition were determined at different temperatures.The rates of oxidation of para and meta-substituted (phenylthio)acetic acids were correlated with Hammett's substituent constants.The ρ value is -1.60 at 35 deg c.The rates of oxidation of ortho substituted compounds are correlated with Charton's triparametric equation.A mechanism involving the decomposition of the intermediate complex in the slow rate-determining step affording a sulphonium ion which hydrolyses in a subsequent fast step to the sulphoxide is proposed.
- Karunakaran, K.,Elango, K. P.
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p. 429 - 434
(2007/10/02)
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- Metalation reactions. XV. Regioselective metalation of (alkylthio)fluorobenzene
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In reactions of (alkylthio)fluorobenzenes with n-butyllithium the compounds 4-RSC6H4F (R = Me, iPr) and 2-iPrSC6H4F were found to undergo metalation selectively ortho to the fluorine atom, whereas 2-MeSC6H4F undergoes metalation at the thiomethyl carbon atom.
- Cabiddu, S.,Fattuoni, C.,Floris, C.,Gelli, G.,Melis, S.
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