cas 705-19-1, 2-(2-METHYL-4-NITRO-IMIDAZOL-1-YL)-ETHANOL | Articles data ｜lookchem

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705-19-1

Articles about 705-19-1Total 3 be found

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Crystal Habit Modification of Metronidazole by Supramolecular Gels with Complementary Functionality
A series of bis(urea) compounds with complementary functional groups similar to the pharmaceutical drug metronidazole and a structural isomer isometronidazole have been synthesized. The gelation properties of these compounds were studied in various solvent/solvent mixtures. The mechanical strength of the isomeric gelators was compared using rheology, and the morphologies of the xerogels were analyzed by scanning electron microscopy. These gels were used as media for metronidazole crystallization resulting in a marked habit modification of the metronidazole crystals in the drug-mimicking gels. However, crystallization in the nonmimetic isomeric gel resulted in morphologies similar to the solution state. These results indicate that the drug-mimetic gels interact with the surface of the drug crystal giving rise to new morphologies.
Jayabhavan, Sreejith Sudhakaran,Steed, Jonathan W.,Damodaran, Krishna K.
p. 5383 - 5393
(2021/08/23)

Structure-activity relationships of antitubercular nitroimidazoles. 1. structural features associated with aerobic and anaerobic activities of 4 - And 5-nitroimidazoles
The 4-nitroimidazole PA-824 is active against aerobic and anaerobic Mycobacterium tuberculosis(Mtb)while 5-nitroimidazoles like metronidazole are active against only anaerobic Mtb. We have synthesized analogues of both 4 - and 5-nitroimidazoles and explor
Kim, Pilho,Zhang, Liang,Manjunatha, Ujjini H.,Singh, Ramandeep,Patel, Sejal,Jiricek, Jan,Keller, Thomas H.,Boshoff, Helena I.,Barry III, Clifton E.,Dowd, Cynthia S.
experimental part
p. 1317 - 1328
(2009/12/07)

Solid-liquid phase-transfer catalytic method for N-alkylation of nitroimidazole
A variety of 1-alkyl-2-methyl-4-nitroimidazoles have been synthesized with a solid-liquid phase-transfer catalytic method in excellent yields.
Liu,Chen,Cao,Li
p. 2611 - 2615
(2007/10/02)

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Chemical Properties

Melting Point: 140 °C
Boiling Point: 405.4 °C at 760 mmHg
Flash Point:199 °C
Density: 1.45 g/cm³
Solubility:DMSO (Slightly), Methanol (Slightly)
Storage Temp.:Refrigerator
PKA: 14.44±0.10(Predicted)
PSA: 83.87000
LogP: 0.61520

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