Harnessing Stereospecific Z-Enamides through Silver-Free Cp?Rh(III) Catalysis by Using Isoxazoles as Masked Electrophiles
The stereospecific synthesis of Z-enamides is described in this paper. For the first time, isoxazoles have been employed as electrophiles in C-H functionalization to afford thermodynamically less stable Z-enamides utilizing salicylaldehydes in an atom- and step-economic fashion. The stereochemistry of enamides might originate from the relative disposition of atoms present in isoxazole and the intramolecular hydrogen bonding. The reaction showed excellent scope as several structurally and electronically diverse salicylaldehydes and isoxazoles reacted efficiently.
A novel synthesis of 5-substituted isoxazoles from propargylic amines and N-hydroxyphthalimide
A mild and efficient method for the synthesis of 5-substituted isoxazoles through cyclization of propargylic amines with N-hydroxyphthalimide (NHPI) under metal-free conditions was developed.
Zhang, Yicheng,Chen, Wei,Jia, Xueshun
supporting information
p. 2181 - 2183
(2018/05/08)
Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity
Woodward's reagent K (WRK) is a reactive heterocyclic compound that has been employed in protein chemistry to covalently and unspecifically label proteins at nucleophilic amino acids, notably at histidine and cysteine. We have developed a panel of WRK-der
Qian, Yong,Schürmann, Marc,Janning, Petra,Hedberg, Christian,Waldmann, Herbert
p. 7766 - 7771
(2016/07/07)
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