- Application of pimavanserin in preparation of antitumor drugs
-
The invention relates to application of pimavanserin in preparation of antitumor drugs, belongs to the technical field of medicines, and particularly relates to novel application of pimavanserin in preparation of antitumor drugs. The structural formula of the pimavanserin is shown in the formula I. The biological activity test of the compound shows that the compound has antitumor activity and is a novel antitumor drug.
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Paragraph 0021; 0026
(2021/08/21)
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- Method for continuously preparing pimavanserin by using micro-channel reactor
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The invention discloses a method for continuously preparing pimavanserin by using a micro-channel reactor. The method comprises the following steps: dissolving a reaction substrate in an organic solvent, pumping the material solution into a micro-channel reactor by using a feeding pump, sufficiently mixing, and carrying out continuous Curtius rearrangement and addition reaction to obtain the pimavanserin. According to the invention, the micro-channel reactor is adopted for reaction, so that the mixing uniformity is good, the reaction time is shortened, and the operation is simple and safe; andthe environmental pollution is obviously reduced.
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- PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL AGENT
-
This invention relates to a process for the preparation of pimavanserin comprising: (i) providing an acid addition salt of pimavanserin; (ii) dissolving the acid addition salt of pimavanserin in an aqueous solvent to form an aqueous solution; (ill) washing the aqueous solution obtained in step (ii) with an organic solvent; and (iv) adding a base to the washed aqueous solution to form pimavanserin. The invention also relates to a process for the preparation of an acid addition salt of pimavanserin additionally comprising step (v) of converting pimavanserin into an acid addition salt of pimavanserin. The invention also relates to pimavanserin or an acid addition salt thereof obtainable by the process, and to the use of pimavanserin hydrochloride, pimavanserin hydrogen sulfate or pimavanserin acetate for preparing pimavanserin or an acid addition salt thereof.
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Page/Page column 17-18
(2020/10/28)
-
- Preparation method of pimavanserin
-
The invention discloses a preparation method of pimavanserin. The method comprises the following steps of taking N-(4-fluorobenzyl)-1-methylpiperidine-4-amine and N, N'-disuccinimido carbonate as rawmaterials in a suitable solvent, performing catalytic reaction by utilizing N-methylmorpholine, directly adding 4-isobutoxybenzylamine without separating an intermediate product, performing reaction,and finally performing separation and purification to obtain the pimavanserin. The synthesis method is simple, efficient, mild in reaction condition, easy to control and high in yield.
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Paragraph 0023-0024; 0025-0031
(2020/07/13)
-
- PROCESS FOR THE MANUFACTURING OF PIMAVANSERIN
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The present invention relates to a new process for manufacturing 1-(4-fluorobenzyl)-3-(4-iso-butoxyphenyl)-1-(1-methylpiperidin-4-yl)urea, with the INN name pimavanserin, and its hemitartrate salt.
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Page/Page column 19-20
(2020/05/28)
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- Preparation method of pimavanserin and intermediate thereof
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The invention discloses a preparation method of pimavanserin and an intermediate thereof. The preparation method of the intermediate comprises the following steps: in the presence of an alkali, carrying out a reaction on a compound M, a compound SM and carbon dioxide in an organic solvent to obtain a compound A, wherein R is C1-C4 alkyl, benzyl or substituted benzyl, and X is Cl, Br or I. The preparation method has the advantages of simple operation, mild reaction conditions, high yield, low impurity content, easy purification, substantial reduction of the production cost, and easy industrialproduction.
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Paragraph 0097-0110
(2020/04/01)
-
- New crystal form of pimavanserin and preparation method thereof
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The invention provides a new crystal form of pimavanserin and a preparation method thereof. CuK alpha radiation is used, and an X-ray powder diffraction pattern has diffraction peaks at least at positions of 4.90 degrees, 5.50 degrees, 6.24 degrees, 8.67 degrees, 14.08 degrees, 14.94 degrees, 18.69 degrees and 19.67 degrees at 2[theta]+/-0.2 degrees; the preparation process is stable, and the prepared new crystal form of pimavanserin has the excellent characteristics of high solubility, good stability, and low hygroscopicity, and has superiority in industrial production.
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Paragraph 0070; 0075-0079
(2020/07/13)
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- A PHARMACEUTICAL INTERMEDIATE
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This invention relates to4-(4-fluorobenzylamino)-1-methylpiperidine trihydrateand a process for the preparation of 4-(4-fluorobenzylamino)-1-methylpiperidine trihydrate comprising treating 4-(4- fluorobenzylamino)-1-methylpiperidine with water. The invention also relates toa process for the preparation of pimavanserin comprising reacting 4-(4- fluorobenzylamino)-1-methylpiperidine trihydrate with 1-isobutoxy-4-(isocyanatomethyl)benzene; toa process for the preparation of a pimavanserin acid addition salt comprising reacting 4-(4- fluorobenzylamino)-1-methylpiperidine trihydrate with 1-isobutoxy-4-(isocyanatomethyl)benzene and converting pimavanserin into a pimavanserinacid additionsalt, pimavanserin and pimavanserin acid addition salts obtainable by the process, and to the use of 4-(4-fluorobenzylamino)-1-methylpiperidine trihydrate for preparing pimavanserin or an acid additionsalt thereof.
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Page/Page column 15; 16
(2020/12/07)
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- An improved process for the preparation of pimavanserin tartrate
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A practical synthetic route to pimavanserin tartrate, in which the target compound was obtained with 99.84% purity and in 46% total yield via a 5-step synthesis starting from 4-hydroxybenzaldehyde and (4-fluorophenyl)methanamine, is reported. The main advantages of the route include inexpensive starting materials, mild reaction conditions and an acceptable overall yield.
- Wu, Caijiao,Zhou, Qifan,Song, Dake,Li, Hui,Bao, Changshun,Liu, Xuelong,Bao, Xuefei,Chen, Guoliang
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p. 480 - 485
(2019/11/03)
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- METHOD FOR THE PREPARATION OF PIMAVANSERIN BASE
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Disclosed is a process for the synthesis of pimavanserin base with a high yield and purity, which comprises: a) converting tert-butyl-N-[(4-propan-2-yloxyphenyl)methyl]carbamate (Formula (I)) to 1-(isocyanatomethyl)-4-propan-2-yloxybenzene of formula (II) b) adding N-[(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine (Formula (IV)) to the solution obtained in a) to give pimavanserin base, and c) purifying the pimavanserin base obtained in step b).
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Page/Page column 10
(2019/11/12)
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- PROCESS FOR THE MANUFACTURING OF PIMAVANSERIN
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The present invention relates to a new process for manufacturing 1 -(4-fluorobenzyl)-3-(4-iso- butoxyphenyl)-1 -(1 -methylpiperidin-4-yl)urea, with the INN name pimavanserin, and its hemi- tartrate salt. Said process comprises the following step: contacting 2-(4-isobutoxyphenyl)acetic acid with N-(4-fluorobenzyl)-1 -methylpiperidin-4-amine in the presence of a base and diphe- nylphosphoryl azide (DPPA) to obtain pimavanserin.
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Page/Page column 16; 17
(2019/10/15)
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- Synthetic method of Pimavanserin
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The invention belongs to the field of medicine synthesis, and especially relates to a synthetic method of Pimavanserin. According to the synthetic method, 4-hydroxy benzoic acid is taken as a raw material, esterification reaction, alkylation reaction, hydrolysis, acylation reaction, dehydration reduction, and acylation reaction are carried out to obtain an intermediate (9); fluorobenzylamine and N-methyl-4-piperidone are taken as raw materials for reductive amination to obtain intermediate (10); and at last the intermediate (9) and the intermediate (10) are subjected to aminolysis to obtain finished product Pimavanserin. The initial raw materials are cheap and easily available; reaction conditions are mild; no column chromatography is needed; and the yield is relatively high.
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- Novel and environmentally friendly synthesis of pimavanserin (5-HT2A receptor)
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Eco-friendly synthesis of pimavanserin was developed from the key starting material 4-isobutoxy benzylamine in three different routes using water as solvent. These reactions provide an advantage of easy workup, good yields of products and uses water as the solvent. No column purification was required for the isolation of the product.
- Rapolu, Rajesh Kumar,V Prasada Raju,Chavali, Murthy,Mulakayala, Naveen
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p. 723 - 726
(2019/02/06)
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- PROCESS FOR THE PREPARATION OF 1-(4-FLUOROBENZYL)-3-(4-ISOBUTOXYBENZYL)-1-(1- METHYLPIPERIDIN-4-YL)UREA AND SALTS THEREOF
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The present invention relates to an efficient process for the preparation of 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1- methylpiperidin-4-yl)urea and pharmaceutically acceptable salts thereof involving use of novel intermediates.
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Page/Page column 12; 13
(2019/01/21)
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- Method used for preparing pimavanserin or salt of pimavanserin
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The invention relates to a method used for preparing pimavanserin or a salt of pimavanserin, and belongs to the field of pharmaceutical technology. The preparation method comprises a following step anamino compound and a novel ester compound are subjected to substitution reaction to prepare pimavanserin. The preparation method is capable of obtaining a high purify product; the technology is clean; efficiency is high; economical benefit is high; intermediate quality is controllable; and the preparation method is suitable for industrialized production.
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Paragraph 0054-0056
(2019/08/07)
-
- Pimavanserin intermediate and preparation method of pimavanserin
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The invention discloses a pimavanserin intermediate and a preparation method of pimavanserin. A structural general formula of the pimavanserin intermediate is shown in the description; the pimavanserin intermediate is prepared by carrying out reductive amination on 4-isobutoxybenzaldehyde and carbamate; a synthesis route is shown in the description; the pimavanserin is obtained through ammonolysisreaction. According to the preparation method of the pimavanserin intermediate, the target intermediate is obtained in one step through reductive amination reaction and reaction steps of the pimavanserin are extremely simplified; used raw materials are safe and the cost is low; reaction conditions are moderate and phosgene which has great toxicity and is uneasy to operate is not used, so that thepreparation method is easy to realize in industry; the intermediate and a product are easy to separate and purify, and the next-step reaction can be directly carried out to prepare the pimavanserin,without the need of separating the pimavanserin; the preparation method is simple to operate and the yield is higher than that of the prior art; the synthesis cost of the pimavanserin is reduced.
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Paragraph 0072; 0077; 0078; 0079
(2018/09/08)
-
- A preparation method of not fan selin vinyl
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The invention discloses a simple and safe preparation method of Pimavanserin. The preparation method comprises the following two steps: 1, dissolving a compound shown in the formula I into an organic solvent I, adding an alkaline medium I and corresponding chloro-carbonic ester, stirring for 1-12h at a temperature between -10 DEG C and 100 DEG C and performing post-treatment to obtain a compound shown in the formula II; and 2, dissolving a compound shown in the formula III into an organic solvent II, adding an alkaline medium II and the compound shown in the formula II, stirring for 1-24h at a temperature between -10 DEG C and 110 DEG C and performing post-treatment to obtain Pimavanserin 8. The preparation method disclosed by the invention has the advantages that water-free treatment is avoided; hypertoxic light and gas are not used; reaction conditions are mild; no special equipment is needed; all intermediates are stable solids, can be subjected to quality control and impurity analysis easily and are insoluble in water; after reaction is finished, products can be separated out by adding water and can be obtained finally through suction filtering and water washing; and therefore, the preparation method of Pimavanserin is suitable for industrial production.
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- Method for Preparing Pimavanserin
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Provided is a method for preparing pimavanserin including reacting an intermediate compound represented by Formula (II) with N-(4-fluorobenzyl)-1-methylpiperidin-4-amine or a salt thereof, or reacting an intermediate compound represented by Formula (IV) with 4-isobutoxybenzylamine or a salt thereof, wherein L represents a heteroaryl group, —OR1 or halogen, and wherein R1 represents C1 to C10 alkyl or aryl. The present disclosure provides the method for preparing pimavanserin without the use of isocyanate intermediate.
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Paragraph 0033
(2018/08/11)
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- PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIMAVANSERIN
-
The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
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- Preparation method of pimavanserin
-
The invention discloses a preparation method of pimavanserin. The preparation method comprises the following steps of mixing 1-(4-fluorobenzyl)-1-(4-methylpiperidyl)urea, 4-isobutoxybenzaldehyde and tetraisopropyl titanate in a solvent, reducing through hydroborate, and then obtaining the pimavanserin through purification. A synthesis method provided by the invention is succinct and high-efficiency, mild in reaction condition, easy to control and high in yield.
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Paragraph 0022
(2018/03/26)
-
- A vinyl [...] lin key intermediate for the preparation of (by machine translation)
-
The invention discloses a matching [...] lin key intermediate of the preparation method. Synthetic route a The method of the invention the raw materials used in safety, and low cost, effectively reduces the production cost. The method of the invention mild reaction conditions, can avoid the toxicity and the operation is not easy to use phosgene, industrial is easy to realize. (by machine translation)
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- Method for safely preparing pimavanserin and tartrate thereof by utilizing triphosgene
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The invention discloses a method for safely preparing pimavanserin and tartrate thereof by utilizing triphosgene. The synthetic route is as shown in the specification. The raw materials used by the method disclosed by the invention are safe, the cost is low, and the production cost is effectively reduced. The method disclosed by the invention is mild in reaction conditions, usage of phosgene thatis high in toxicity and difficult to operate can be avoided, and industrial production is easily realized.
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- A PRODUCTION METHOD OF 1-(4-FLUOROBENZYL)-3-(4-ISOBUTOXYBENZYL)-1-(1-METHYLPIPERIDIN- 4— YL)UREA AND ITS DEUTERATED ANALOGS NOT CONTAINING DIMERIC IMPURITIES
-
The invention relates to an improved production method of 1-(4-fluorobenzyl)-3-(4-- isobutoxybenzyl)-1-(1— methylpiperidin-4-yl)urea of formula I, known under the generic name of pimavanserin. The method consists of two steps, namely a reaction of N-(4- fluorobenzyl)-l-methylpiperidine-4-amine with cyanic acid, the next step being a reaction of the obtained compound from the first step, 1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea and 4-isobutoxybenzaldehyde or with its precursors. Pimavanserin is an inverse agonist of the serotonin 5-HT2A receptor and is currently in the tartrate form in stage III of clinical trial for the treatment of psychosis in patients suffering from Parkinson's disease and has potential to become part of the therapy of other psychotic conditions.
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Page/Page column 19
(2017/03/21)
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- Pimavanserin monotartrate hemihydrate and preparation method thereof
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The invention provides a new pimavanserin crystal form, namely a monotartrate hemihydrate; a powder X-ray diffraction pattern of the polycrystal form has diffraction peaks at about (2[theta]+/-0.2 degrees) 7.1 degrees, 15.6 degrees, 18.6 degrees, 20.6 degrees and 22.9 degrees. The crystal form is easy to prepare, simple to operate, and better suitable for preparation of pharmaceutical preparations and large-scale production, and has broad application prospects.
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Paragraph 0020; 0021; 0022
(2017/08/30)
-
- Preparation method for pimavanserin
-
The invention relates to a one-pot preparation method for pimavanserin. The method prepares pimavanserin (a compound IV) from 4-isobutoxybenzylamine as shown in a formula (II) or a salt thereof, a carbonylation reagent as shown in a formula (III) and N-(4-fluorobenzyl)-1-methylpiperidin-4-amine as shown in a formula (I) by using a one-pot process. The method is highly efficient, high in yield, low in cost, safe, environment friendly and suitable for industrial production, and has great application value.
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Paragraph 0041; 0042
(2017/08/28)
-
- Method for preparing pimavanserin and tartrate thereof
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The invention provides an improved method for preparing pimavanserin and tartrate thereof. The method comprises the following steps: taking a compound 4-(4-fluorobenzylamino)-1-methylpiperidine as a starting material and carrying out acylation reaction on the starting material and triphosgene in the presence of triethylamine to prepare a compound (4-fluorobenzyl)-(1-methylpiperidine-4-yl)carbamyl chloride; then taking the (4-fluorobenzyl)-(1-methylpiperidine-4-yl)carbamyl chloride and 4-isobutoxybenzylamine to react in the presence of triethylamine, so as to prepare the pimavanserin and the tartrate thereof. The method provided by the invention is simple, efficient and economical and the quality of an intermediate is controllable, so that the method is suitable for industrial preparation.
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Paragraph 0068; 0073; 0075; 0077; 0079; 0080; 0081
(2017/11/04)
-
- A PRODUCTION METHOD OF 1-(4-FLUOROBENZYL)-3-(4-ISOBUTOXYBENZYL)-1-(1-METHYLPIPERIDIN- 4-YL)UREA AND ITS DEUTERATED ANALOGS
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The present invention relates to an improved production method of 1-(4-fluorobenzyl)-3-(4--isobutoxybenzyl)-1-(1--methylpiperidin-4-yl)urea (Pimavanserin), an inverse agonist of the serotonin 5-HT2A receptor of formula (I). Crude pimavanserin prepared by this method contains a very low quantity of the disubstituted impurity.
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Page/Page column 5-6
(2017/05/07)
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- A preparation method of not fan selin vinyl
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The invention discloses a preparation method of pimavanserin. The method comprises the following two steps: firstly, 4-isobutoxy benzene methylamine and carbonyl diimidazole are subjected to acylation reaction to obtain N-(4-isobutoxy phenyl)-1H-imidazole-1-formamide, and the N-(4-isobutoxy phenyl)-1H-imidazole-1-formamide and N-(4-fluorophenyl)-1-methylpiperidine-4-amine are subjected to urea reaction, so as to obtain the pimavanserin. The prepared pimavanserin is good in quality and high in yield, the reagent toxicity is relatively low, the operation is simple and easy to control, and the pimavanserin is suitable for industrial production.
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Paragraph 0013; 0040-0049
(2017/10/13)
-
- METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C
-
Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(l-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is -ORi or -NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is -OR22 or -NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N- methylpiperidin-4-yl); and R21 is -OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(l-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.
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Paragraph 0259
(2017/02/09)
-
- Preparation method of Pimavanserin
-
The invention discloses a preparation method of Pimavanserin. The preparation method comprises the following steps: (1) adopting 4-isobutoxy benzaldehyde to react with hydroxylamine hydrochloride in an alkaline liquor to prepare 4-isobutoxy benzaldoxime; (2) adopting a reducing agent to reduce the 4-isobutoxy benzaldoxime so as to generate 4-isobutoxy benzylamine; (3) adopting a carbonyl compound to react with the 4-isobutoxy benzylamine to prepare N-(4-isobutoxy benzyl) phenyl carbamate; and (4) adopting the N-(4-isobutoxy benzyl) phenyl carbamate to react with N-(4-fluorobenzyl)-1-methyl piperidine-4-amine, and thus obtaining the Pimavanserin. Heating is not needed when the 4-isobutoxy benzaldoxime is prepared in the method, so that the energy consumption is reduced; zinc powder is used for replacing hydrogen and palladium carbon so as to generate the 4-isobutoxy benzylamine, and low-cost easily-obtained diphenyl carbonate is used for replacing hypertoxic carbonyl chloride and expensive DPPA, so that the safety is improved, and the environmental protection is facilitated.
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Paragraph 0023; 0024; 0032; 0033; 0041; 0042; 0050; 0051
(2017/10/07)
-
- A process for preparing matching ma Selin method (by machine translation)
-
The invention relates to a method for preparing vinyl ma Selin. The method in order to 4 - isobutyl phenyl ether as a starting material, mild reaction conditions, to avoid the gas reaction material, the product yield is high, simple process operation, without special equipment requirements, particularly suitable for industrial production. (by machine translation)
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- Novel synthesis method for pimavanserin
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The invention provides a novel synthesis method for pimavanserin. The method comprises the steps that a compound formula (1a) is adopted as a raw material for preparing an active urea compound formula (1) and then subjected to a reaction with a compound formula (2) under an alkaline system to obtain a pimavanserin free alkali formula (3), and then pimavanserin free alkali forms a salt with tartaric acid to obtain a pimavanserin half tartrate formula (4). The method is simple in technological path, low in cost and suitable for industrial production. The formula is shown in the description, wherein HmA is the general formula of m-basic acid, HnA is the general formula of n-basic acid, m and n are 1 or 2 or 3, and the m-basic acid and the n-basic acid are selected from sulfuric acid, hydrochloric acid, phosphoric acid, p-toluenesulfonic acid, benzenesulfonic acid, methanesulfonic acid, methanoic acid, acetic acid, trifluoroacetic acid, oxalic acid, citric acid or tartaric acid.
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- Preparation method of pimavanserin
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The invention relates to a preparation method of pimavanserin. The preparation method takes 4-fluorobenzylamine as a raw material and comprises the following steps: performing reductive amination on the 4-fluorobenzylamine and N-methyl-4-piperidone; performing butt joint on the product and benzyl chloroformate; finally, reacting with 4-isobutoxybenzylamine to prepare the pimavanserin. The preparation method provided by the invention is simple, convenient and feasible, has high yield and good quality and is convenient for industrial production.
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Paragraph 0073; 0074
(2016/11/24)
-
- Preparation method of 5-HT2A inverse agonist ACP-103
-
The invention discloses a preparation method of 5-HT2A inverse agonist ACP-103. The method includes: in the presence of borohydride, subjecting 4-fluorobenzylamine and N-methyl-4-piperidone to reaction to obtain a compound as shown in the formula 3; in the presence of inorganic base, subjecting methyl 4-hydroxyphenylacetate and 1-bromo-2-methylpropane to reaction to obtain a compound as shown in the formula 6; subjecting the compound as shown in the formula 6 to reaction with inorganic base to obtain a compound as shown in the formula 7; subjecting the compound as shown in the formula 7 to reaction with an acyl chloride reagent to obtain a compound as shown in the formula 8; in the presence of tetrabutylammonium bromide, subjecting the compound as shown in the formula 8 to reaction with sodium azide to obtain a compound as shown in the formula 9; subjecting the compound as shown the formula 9 and the compound as shown in the formula 3 to reaction to obtain the compound ACP-103 as shown in the structural formula. The preparation method of the 5-HT2A inverse agonist ACP-103 is mild in reaction condition and high in yield.
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- Intermediate of pimavanserin and similar compound thereof, and preparation method thereof, and method for preparing pimavanserin and similar compound thereof
-
The present invention relates to an intermediate of pimavanserin and a similar compound thereof, and a preparation method thereof, and a method for preparing pimavanserin and a similar compound thereof. According to the present invention, the raw materials required by the intermediate have characteristics of low price, easy obtaining, easy separation purification and no requirement of post-treatment, the next step reaction can be directly performed through the one-pot method to prepare the pimavanserin and the similar compound thereof, the operation is simple, and the economical, efficient, safe and environmentally friendly synthesis process is provided for the preparation of the pimavanserin and the similar compound thereof; and with the application of the intermediate to prepare the pimavanserin, the high toxicity and the use of the difficultly-operated phosgene can be avoided, and the total yield of the reaction can achieves the level in the prior art even the higher level.
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Paragraph 0091; 0092; 0093
(2016/10/09)
-
- METHODS FOR THE TREATMENT OF PARKINSON'S DISEASE PSYCHOSIS USING PIMAVANSERIN
-
Methods for the treatment of Parkinson's disease psychosis which comprise the administration of pimavanserin.
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-
-
- SUBSTITUTED UREAS
-
Disclosed herein are urea-based 5-HT receptor modulators, pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and medical use of such compounds for the treatment and/or management of 5-HT receptor-mediated disorders.
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Page/Page column 22
(2008/12/08)
-
- SALTS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND THEIR PREPARATION
-
Disclosed herein are salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide of formula (I) including the citrate, fumarate, maleate, malate, phosphate, succinate, sulphate, and edisylate salts.
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Page/Page column 23
(2008/06/13)
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