- HETEROARYL SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF
-
The present disclosure provides a compound of Formula (I): (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx and X1 are as defined herein, and methods of making and using same.
- -
-
Page/Page column 340-341
(2022/02/15)
-
- Access to 4-alkylaminopyridazine derivatives via nitrogen-assisted regioselective pd-catalyzed reactions
-
3-Substituted, 6-substituted, and unsymmetrical 3,6-disubstituted 4-alkylaminopyridazines were prepared from a sequence of three chemo- and regioselective reactions combining amination and palladium-catalyzed cross-coupling reactions, such as reductive dehalogenation and Suzuki-Miyaura reactions. Extension of the methodology to Sonogashira reaction yielded a novel class of 3-substituted pyrrolopyridazines.
- Blaise, Emilie,Kümmerle, Arthur E.,Hammoud, Hassan,De Arajo-Jnior, Jo Xavier,Bihel, Frdric,Bourguignon, Jean-Jacques,Schmitt, Martine
-
p. 10311 - 10322
(2015/02/19)
-