- Process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines
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A process for the optical resolution of racemic 1,4-dihydropyridines, containing isothioureido groups. Salification of racemic isothioureas with optically active acids produces diasteroisomeric mixtures of isothiouronium salts, that, using conventional techniques, are separated in the individual components to give optically pure isothioureides of 1,4-dihydropyridines and salts thereof with conventional acids. Said optically pure 1,4-dihydropyridines can then be subjected to desulphuration and to different transformations to give to other enantiomerically pure and therapeutically useful 1,4-dihydropyridines.
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- Mixtures of optically active nitrodihydropyridines active on the circulatory system
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Pure enantiomers of 5-nitrodihydropyridine of the formula STR1 are mixed, wherein one of the enantiomers has a high vasodilative action and a low negative inotropic activity on heart muscle, the other enantiomer has a low vasoconstrictive action and a hig
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- Method of combatting coronary and vascular diseases
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1,4-Dihydropyridines of the formula STR1 in which n is 0,1 or 2, and R1 to R7 can have a wide variety of meanings, which possess inotropic action, and many of which are new, are useful in increasing the influx of Ca++ into
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- Nitro-substituted 1,4-dihydropyridines, processes for _their production and their medicinal use
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The invention includes novel nitro-substituted 1,4-dihydropyridines useful because of their influence on the circulation. Also included in the invention are methods for the preparation of said novel nitro-substituted 1,4-dihydropyridines, compositions con
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