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Handling heme: The mechanisms underlying the movement of heme within and between cells
Heme is an essential cofactor and signaling molecule required for virtually all aerobic life. However, excess heme is cytotoxic. Therefore, heme must be safely transported and trafficked from the site of synthesis in the mitochondria or uptake at the cell surface, to hemoproteins in most subcellular compartments. While heme synthesis and degradation are relatively well characterized, little is known about how heme is trafficked and transported throughout the cell. Herein, we review eukaryotic heme transport, trafficking, and mobilization, with a focus on factors that regulate bioavailable heme. We also highlight the role of gasotransmitters and small molecules in heme mobilization and bioavailability, and heme trafficking at the host-pathogen interface.
Donegan, Rebecca K.,Moore, Courtney M.,Hanna, David A.,Reddi, Amit R.
p. 88 - 100
(2018/08/21)

Biosynthesis of Porphyrins and Related Macrocycles. Part 18. Proof by Spectroscopy and Synthesis that Unrearranged Hydroxymethylbilane is the Product from Deaminase and the Substrate for Cosynthetase in the Biosynthesis of Uropophyrinogen-III
When the enzyme deaminase acts alone on porphobilinogen, it releases a tarnsient intermediate into the medium which is unaffected by further treatment with a large excess of deaminase.The intermediate undergoes rapid ring-closure chemically (t1/2/su
Battersby, Alan R.,Fookes, Christopher J. R.,Gustafson-Potter, Kerstin E.,McDonald, Edward,Matcham, George W. J.
p. 2427 - 2444
(2007/10/02)