'Reagent explosion': An efficient method to increase library size and diversity
Methyl-β-(N,N-dialkylamino)-α-isocyanoacrylates, readily prepared from the reaction between various secondary amines, N-formylimidazole diethylacetal and methyl isocyanoacetate can be used to increase the diversity of the isonitrile input in multi-compone
PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS
The present invention relates to compounds of formula (I) useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and the compounds for use in methods for the treatment of various disorders. Formula (I): or a salt thereof, wherein: A is selected from the group consisting of:
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(2016/05/02)
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