Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK)
The present invention relates to a method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) and the use of the compounds in the prevention or treatment of disease, including pre-diabetes, type 2 diabetes, syndrome X, metabolic syndrome and obesity.
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Paragraph 0051-0052
(2014/10/16)
Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells
To study the structure-activity relationships of aromatic cytokinins, the cytokinin activity at both the receptor and cellular levels, as well as CDK inhibitory and anticancer properties of 38 6-benzylaminopurine (BAP) derivatives were compared in various
Dolezal, Karel,Popa, Igor,Krystof, Vladimir,Spichal, Lukas,Fojtikova, Martina,Holub, Jan,Lenobel, Rene,Schmuelling, Thomas,Strnad, Miroslav
p. 875 - 884
(2007/10/03)
Structure-Activity Relationships of 9-Alkyladenine and Ribose-Modified Adenosine Derivatives at Rat A3 Adenosine Receptors
9-Alkyladenine derivatives and ribose-modified N6-benzyladenosine derivatives were synthesized in an effort to identify selective ligands for the rat A3 adenosine receptor and leads for the development of antagonists.The derivatives
Jacobson, Kenneth A.,Siddiqi, Suhaib M.,Olah, Mark E.,Ji, Xiao-duo,Melman, Neli,et al.
p. 1720 - 1735
(2007/10/02)
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