Preparation of 2-aminopyridoimidazoles and 2-aminobenzimidazoles via phosphorus oxychloride-mediated cyclization of aminoureas
The novel preparation of 2-aminopyridoimidazoles and 2-aminobenzimidazoles via the cyclization of (2-aminopyridin-3-yl)urea and (2-aminophenyl)urea substrates in the presence of phosphorus oxychloride is described. This methodology is demonstrated for a range of urea substrates with aminoimidazole products obtained in good yields and with excellent levels of purity.
Deasy, Rebecca E.,Slattery, Catherine N.,Maguire, Anita R.,Kjell, Douglas P.,Hawk, Mai Khanh N.,Joo, Jung Min,Gu, Rui Lin,Moynihan, Humphrey
p. 3688 - 3695
(2014/05/06)
Specific features of nucleophilic substitution in 1-chloro-3,4- dinitrobenzene
Effects of the solvent, temperature, and nucleophile nature on the selectivity of nucleophilic substitution in 1-chloro-3,4-dinitrobenzene were studied, and optimal conditions were found for the synthesis and isolation of particular products.
Zotova,Kushakova,Kuznetsov,Rodin,Garabadzhiu
p. 1473 - 1476
(2007/10/03)
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