- Visible-light-promoted synthesis of secondary and tertiary thiocarbamates from thiosulfonates andN-substituted formamides
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A general visible-light-promoted metal-free synthesis of secondary and tertiary thiocarbamates starting from thiosulfonates andN-substituted formamides is developed. By employing rhodamine B as a photocatalyst andtert-butyl hydroperoxide (TBHP) as an oxidant, a wide scope of thiocarbamates can be obtained through direct thiolation of acyl C-H bonds under irradiation of blue light at room temperature for 12 h.
- Bi, Wen-Zhu,Zhang, Wen-Jie,Li, Zi-Jie,He, Yuan-Hao,Feng, Su-Xiang,Geng, Yang,Chen, Xiao-Lan,Qu, Ling-Bo
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p. 8701 - 8705
(2021/10/22)
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- Electrochemically Catalyzed Newman-Kwart Rearrangement: Mechanism, Structure-Reactivity Relationship, and Parallels to Photoredox Catalysis
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The facilitation of redox-neutral reactions by electrochemical injection of holes and electrons, also known as "electrochemical catalysis", is a little explored approach that has the potential to expand the scope of electrosynthesis immensely. To systematically improve existing protocols and to pave the way toward new developments, a better understanding of the underlying principles is crucial. In this context, we have studied the Newman-Kwart rearrangement of O-arylthiocarbamates to the corresponding S-aryl derivatives, the key step in the synthesis of thiophenols from the corresponding phenols. This transformation is a particularly useful example because the conventional method requires temperatures up to 300 °C, whereas electrochemical catalysis facilitates the reaction at room temperature. A combined experimental-quantum chemical approach revealed several reaction channels and rendered an explanation for the relationship between the structure and reactivity. Furthermore, it is shown how rapid cyclic voltammetry measurements can serve as a tool to predict the feasibility for specific substrates. The study also revealed distinct parallels to photoredox-catalyzed reactions, in which back-electron transfer and chain propagation are competing pathways.
- Roesel, Arend F.,Ugandi, Mihkel,Huyen, Nguyen Thi Thu,Májek, Michal,Broese, Timo,Roemelt, Michael,Francke, Robert
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p. 8029 - 8044
(2020/07/25)
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- Microwave-mediated Newman-Kwart rearrangement in water
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For the first time the unimolecular Newman-Kwart rearrangement is performed in pure water. The elevated temperatures required for the 1,3-aryl shift are easily accomplished by microwave irradiation. Differently functionalized substrates underline the expe
- Hoffmann, Ina,Schatz, Jürgen
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p. 80692 - 80699
(2016/09/09)
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- The molecularity of the Newman-Kwart rearrangement
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It was recently reported that the venerable Newman-Kwart rearrangement (1→2) proceeds via mixed first- and second-order kinetics. Prior to this, the rearrangement had been considered to proceed exclusively via an intramolecular OAr→SAr migration. A new bimolecular pathway, possibly involving an 8-membered cyclic transition state, was proposed to account for reaction rates that increased disproportionately with substrate concentration under microwave heating conditions. We report a reanalysis of the kinetics and molecularity of the rearrangement of N,N-dimethyl O-(p-nitrophenyl)thiocarbamate 1a in N,N-dimethylacetamide solvent. Using HPLC, isotopic labeling (2H, 18O, 34S), and ESI-ICRMS methods, we show that there is no evidence for a bimolecular pathway en route to 2a, with near-perfect exponential decay in 1a at concentrations ranging from 0.11 to 4.70 M. Instead, it is demonstrated that under the microwave heating conditions, a delayed negative feedback signal to the microwave power balancing loop results in oscillatory reaction overheating. Due to higher tan δ in the solute, the amplitude of this oscillation increases with the concentration of 1a, and this phenomenon best accounts for the kinetic behavior previously misinterpreted as being mixed 'irst- and second-order in nature.
- Burns, Matthew,Lloyd-Jones, Guy C.,Moseley, Jonathan D.,Renny, Joseph S.
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supporting information; experimental part
p. 6347 - 6353
(2010/12/19)
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- A comparison of commercial microwave reactors for scale-up within process chemistry
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Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman-Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales. Overall, all reactors gave reliable scale-up from small scale, and performance equivalent to one another on large scale. A more detailed comparison between them is given in the concluding section.
- Moseley, Jonathan D.,Lenden, Philip,Lockwood, Mark,Ruda, Katinka,Sherlock, Jon-Paul,Thomson, Anthony D.,Gilday, John P.
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- Scaling-out pharmaceutical reactions in an automated stop-flow microwave reactor
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Six pharmaceutically relevant reactions were assessed for scaleout in an automated stop-flow microwave reactor. Daily throughputs of between 50 and 250 g were achieved at typical reaction concentrations; for more concentrated reactions, or with 24 h proce
- Moseley, Jonathan D.,Woodman, Emily K.
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p. 967 - 981
(2013/01/03)
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- The Newman-Kwart rearrangement: A microwave kinetic study
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(Chemical Equation Presented) The kinetic profile of the Newman-Kwart rearrangement has been evaluated using microwave heating. After first demonstrating equivalence between conventional convective heating and microwave heating, data was gathered and anal
- Gilday, John P.,Lenden, Philip,Moseley, Jonathan D.,Cox, Brian G.
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p. 3130 - 3134
(2008/09/19)
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- The Newman-Kwart rearrangement re-evaluated by microwave synthesis
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The Newman-Kwart rearrangement (NKR) has been re-evaluated by microwave heating. Microwave technology has proven to be ideal for investigating this high temperature rearrangement and facilitated the confirmation of many aspects of this valuable reaction.
- Moseley, Jonathan D.,Sankey, Rosalind F.,Tang, Olivier N.,Gilday, John P.
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p. 4685 - 4689
(2007/10/03)
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- Potassium fluoride on alumina: Synthesis of O-aryl N,N-dimethylthiocarbamates and their rearrangement into S-aryl N,N-dimethylthiocarbamates under microwave irradiation
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A series of O-aryl N,N-dimethyl thiocarbamates have been prepared by the reaction of dimethylthiocarbamoyl chloride with phenols absorbed on potassium fluoride on alumina. The rearrangement of O-aryl N,N-dimethylthiocarbamate into S-aryl N,N-dimethylthiocarbamate under microwave irradiation was also studied. The use of conductive support like graphite or silicon carbide allow these rearrangements although the O-aryl N,N-dimethylthiocarbamates have very low dielectric lost.
- Villemin, Didier,Hachemi, Messaoud,Lalaoui, Mekki
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p. 2461 - 2471
(2007/10/03)
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- Infrared Spectra and Transmission of Electronic Effects in Substituted Phenyl N,N-Dimethylcarbamates and S-Phenyl N,N-Dimethylthiocarbamates
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Carbonyl stretching frequencies in CCl4 and CHCl3 and hydroxyl stretching frequency shifts of phenol as a proton donor in CCl4 were measured for series of substituted phenyl N,N-dimethylcarbamates (I) and S-phenyl N,N-dimethylthiocarbamates (II).The data
- Perjessy, Alexander,Jones, Ronald G.,McClair, Susan L.,Wilkins, Joyce M.
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p. 1266 - 1271
(2007/10/02)
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- Methods for controlling fungi
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Both novel and known S-(substituted-phenyl) N-alkylthiolcarbamates such as 4-fluorophenyl N-methylthiolcarbamate, and S-(substituted-phenyl) N,N-dialkylthiolcarbamates such as 2-chlorophenyl N,N-dimethylthiolcarbamate are disclosed. These are useful to control plant pests such as Phytophthorans infestans (Late Blight of Tomatoes) and Pythium ultimum (Damping Off). Also disclosed are the methods of controlling this plant pest with these compounds.
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