- Design, synthesis, and evaluation of substance P analogue with potential anti-pseudoallergic activity
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Mast cells (MCs) are innate immune cells that can cause allergic reactions. Pseudo-allergic reactions are a type of reaction that have the clinical symptoms of an allergy without involving the IgE pathway of immune MCs. Some studies have found that the MR
- Ge, Shuai,He, Huaizhen,Hou, Yajing,Lu, Jiayu,Lv, Yuexin,Wang, Cheng,Wang, Xiangjun,Yang, Xinyue,Zhang, Ting
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p. 17584 - 17591
(2021/10/04)
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- Kinetically controlled peptide synthesis mediated by papain using the carbamoylmethyl ester as an acyl donor
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A series of dipeptides were synthesized generally in good yields with carbamoylmethyl (Cam) esters as acyl donors in the presence of a cysteine protease, papain, immobilized on Celite. Several segment condensations were also achieved generally in high yields without danger of racemization and formation of the secondary-hydrolysis product. Moreover, partial sequences of some bioactive peptides were prepared through segment condensations, and aimed-at peptides were obtained generally in high yields without the racemization of C-terminal residues of the carboxyl components. Thus, the superiority of the Cam ester in the kinetically controlled peptide synthesis was once again ascertained in couplings mediated by the cysteine protease as in those catalyzed by the serine proteases reported earlier.
- Miyazawa, Toshifumi,Horimoto, Takao,Tanaka, Kayoko
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p. 371 - 376
(2014/08/18)
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- Synthesis of substance-P C-terminal hexapeptide analogues and their biological activity. Analogues with antagonistic activity without containing D-amino acids
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Analogues of the C-terminal hexapeptide of substance P have been synthesized in which each amino-acid residue was replaced by the bulky and strong lipophilic residue Asp(OBzl). The amino-acid residue of other selected places has also been replaced by Glu(
- Karagiannis,Manopoulou,Poulos,Stavropoulos
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p. 667 - 673
(2007/10/02)
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- Conformationally Restricted C-Terminal Peptides of Substance P. Synthesis, Mass Spectral Analysis and Pharmacological Properties
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Four cyclic analogues of the C-terminal hepta- or hexapeptide of substance P were prepared by the solution method.The cyclizations were obtained by substituting with cysteine the residues normally present in positions 5 or 6 or 11 of substance P and by su
- Theodoropoulos, Dimitrios,Poulos, Constantin,Gatos, Dimitrios,Cordopatis, Pane,Escher, Emanuel,et al.
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p. 1536 - 1539
(2007/10/02)
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- Model Studies on Papain-Catalyzed Peptide Synthesis in a Biphasic Aqueous-Organic System
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Several model peptides have been synthesized enzymatically using papain as a catalyst in biphasic aqueous-organic systems.The effect of different cosolvents, pH, buffer concentration, and reaction time on the papain-catalyzed synthesis was examined.A comp
- Doering, Guenter,Kuhl, Peter,Jakubke, Hans-Dieter
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p. 1165 - 1174
(2007/10/02)
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- SYNTHESIS OF PENTAPEPTIDES RELATED BOTH TO SUBSTANCE P C-TERMINAL FRAGMENT AND MET-ENKEPHALIN
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Six pentapeptide amides related both to Substance P C-terminal fragment and to Met-enkephalin have been synthesized.Syntheses were effected by coupling fragments 3 + 2 in solution.The DCC + HOBt method was used for synthesis of peptide fragments and final
- Lipkowski, Andrzej W.,Misicka, Aleksandra,Drabarek, Stefania
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p. 813 - 818
(2007/10/02)
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