- Thermic conversion of benzene into 6-phenylfulvene with high yield mediated by GaP nanocrystals
-
With GaP nanocrystals being used in a close reaction system, 6-phenylfulvene is successfully obtained via a high yield thermic conversion from benzene, which provides the possibility of applying nanocrystals to mediate organic reactions.
- Gao, Shanmin,Lu, Jun,Zhao, Yan,Chen, Nan,Xie, Yi
-
-
Read Online
- New titanocene derivatives with high antiproliferative activity against breast cancer cells
-
The synthesis and characterization of some new titanocene-complexes, having a ethenyl-phenoxide or a benzyl group as substituents of the cyclopentadienyl rings, are reported. The synthesized compounds have been evaluated for their cytotoxic potential against two human breast cancer cell lines, that is: MCF7 and SkBr3. Most of these compounds have shown significant cytotoxic effects, compared to cisplatin, in MTT-based cell tests.
- Saturnino, Carmela,Sirignano, Esther,Botta, Antonio,Sinicropi, Maria Stefania,Caruso, Anna,Pisano, Assunta,Lappano, Rosamaria,Maggiolini, Marcello,Longo, Pasquale
-
-
Read Online
- Kinetics and Mechanism of Pyrrolidine Buffer-Catalyzed Fulvene Formation
-
Rapid synthesis of fulvenes is achieved using pyrrolidinium/pyrrolidine buffers in anhydrous acetonitrile. Time-dependent UV-vis absorption and NMR spectroscopy reveal that the rate and yield of fulvene formation depend strongly on both the presence of acid in the medium and the choice of solvent, and they are negatively affected by water. Kinetic data have been collected for various substrates, and the synthetic benefits of the adjusted reaction conditions are showcased. Enhancements of reaction rates are found in comparison to literature procedures. α-Unsaturated fulvenes that were previously difficult to access can now be obtained in good yields.
- Sieverding, Paul,Osterbrink, Johanna,Besson, Claire,K?gerler, Paul
-
p. 486 - 494
(2019/01/11)
-
- METALLOCENE COMPOUND, CATALYST COMPOSITION COMPRISING THE SAME, AND METHOD FOR PREPARING OLEFIN-BASED POLYMER USING THE SAME
-
The present invention relates to a novel metallocene compound, a catalyst composition comprising the same, and a method for preparing an olefin-based polymer using the same. According to the present invention, the metallocene compound can show excellent activity in a copolymerization reaction of ethylene and alpha-olefin, and can provide an olefin-based polymer which has low molecular weight and high content of comonomers.COPYRIGHT KIPO 2015
- -
-
Paragraph 0090-0092
(2017/01/02)
-
- Synthesis, characterization and cytotoxic activity on breast cancer cells of new half-titanocene derivatives
-
A series of novel titanocene-complexes has been prepared and evaluated for their growth regulatory effects in MCF7 and SkBr3 breast cancer cells. The capability of some of these compound to elicit relevant repressive effects on cancer cell growth could be taken into account towards novel pharmacological approaches in cancer therapy.
- Sirignano, Esther,Saturnino, Carmela,Botta, Antonio,Sinicropi, Maria Stefania,Caruso, Anna,Pisano, Assunta,Lappano, Rosamaria,Maggiolini, Marcello,Longo, Pasquale
-
p. 3458 - 3462
(2013/06/27)
-
- An efficient catalytic method for fulvene synthesis
-
The effects of the nature and amount of base, substrate structure, amount of added water and solvent on the condensation of carbonyl compounds with cyclopentadiene in the presence of secondary amines were investigated. Based on these studies, a new efficient and green synthesis of fulvenes was developed.
- Cokun, Necdet,Erden, Ihsan
-
experimental part
p. 8607 - 8614
(2011/11/30)
-
- Cp*Li as a base: application to palladium-catalyzed cross-coupling reaction of aryl-X or alkenyl-X (X=I, Br, OTf, ONf) with terminal acetylenes
-
The reaction of aryl-X or alkenyl-X (X=I, Br, OTf, ONf) with terminal acetylenes in the presence of a catalytic amount of Pd(OAc)2 provided the alkynylated products in good yields by using Cp*Li (Cp*=1,2,3,4,5-pentamethylcyclopentadienyl) as a base.
- Uemura, Minoru,Yorimitsu, Hideki,Oshima, Koichiro
-
p. 1829 - 1833
(2008/09/18)
-
- A novel reaction of titanacyclopentenes and aldehydes with or without Lewis acids
-
Oxatitanacyclopentenes were prepared in high yields from the reaction of aldehydes with titanacyclopenetens via substitution of ethylene. No insertion product was obtained in this reaction. The combination of alkynes and aldehydes played an important role in the successive formation of oxatitanacyclopentenes. Some oxatitanacyclopentenes are very stable and can be purified using column chromatography. The cooperation between Ti and LA led to very different results from that between Zr and LA.
- Hu, Qiaoshu,Li, Dongzhen,Zhang, Huijun,Xi, Zhenfeng
-
p. 6167 - 6170
(2008/03/12)
-
- Alkylation of carbonyl compounds with dialkylzirconocene complexes promoted by potassium t-butoxide
-
Potassium t-butoxide promotes alkylation of non-enolizable ketones and aldehydes by zirconocene dialkyls. The reaction proceeds with loss of cyclopentadienide ion from the metal center.
- Larson,Baker,Towne,Straus
-
p. 5893 - 5894
(2007/10/02)
-
- A new synthesis of substituted fulvenes
-
A new fulvene synthesis results from the palladium-catalyzed [2 + 2 + 2] annulation of 1 mol of a β-substituted vinyl iodide and 2 mol of a monosubstituted acetylene. This variant of the Heck reaction tolerates a wide range of substrate substituents with
- Lee, Gary C. M.,Tobias, Brian,Holmes, Judy M.,Harcourt, Dale A.,Garst, Michael E.
-
p. 9330 - 9336
(2007/10/02)
-
- REACTION OF DICYCLOPENTADIENYLYTTRIUM CHLORIDE WITH ALDEHYDES AND KETONES. A NOVEL CLEAVAGE REACTION OF Cp-Y ?-BOND
-
Dicyclopentadienylyttrium chloride reacts with aldehydes and ketones at 80 deg C in DME, generating fulvenes in excellent yields, while at lower temperature affording, after hydrolysis, cyclopentadienyl substituted alcohols.
- Qian, Changtao,Qiu, Aineng
-
p. 6931 - 6934
(2007/10/02)
-
- Carbene Reactions, XVIII. Thermal Behaviour of 7-Alkylidenebicycloheptadiene Derivatives
-
Thermolysis of 7-alkylidenenorbornadienes 2 results in a retro-Diels-Alder cleavage to fulvenes and acetylene.A different mode of cleavage - into benzene and a carbene - is observed with such derivatives of 2 which carry ?- or ?-donor functions at C-8.The dependence of the reaction pathways on the nature of the substituent at C-8 is discussed on the basis of MO-calculations.
- Hoffmann, Reinhard W.,Riemann, Achim,Mayer, Bernhard
-
p. 2493 - 2513
(2007/10/02)
-
- An Exceptionally Simple and Efficient Method for the Preparation of a Wide Variety of Fulvenes
-
A simple high yield method for the preparation of a wide range of structurally diverse fulvenes is described.Pyrrolidine proves to be a very effective reagent to promote fulvene formation between cyclopentadiene and a host of carbonyl compounds including simple ketones, 4-tetrahydrothiopyranone, 4-tetrahydropyranone, aldehydes bearing acidic α hydrogens, sterically encumbered aldehydes, as well as optically pure tetrahydrofuranyl aldehydes.With the exception of sterically hindered ketones such as 2,6-dimethylcyclohexanone, the reaction proceeds in acceptable to excellent yieds.The effect of variation of temperature, solvent, and concentration upon the course of the reaction was examined qualitatively.Methanol proved to be the solvent of choice.Deuterium-hydrogen exchange experiments (between MeOD, starting materials, and product) were conducted and it was found that deuterium can be encorporated both before and after fulvene formation.Epimerization of the optically pure fulvene 4 occurred to the extent of 12percent.
- Stone, Keith J.,Little, R.Daniel
-
p. 1849 - 1853
(2007/10/02)
-
- 6,6-DIMETHYL-6-SILAFULVENE. GENERATION AND TRAPPING REACTIONS
-
6,6-Dimethyl-6-silafulvene generated from (allyl)(cyclopentadienyl)-dimethylsilane reacts with a trapping reagent such as methanol, benzaldehyde, and benzophenone to give (cyclopentadienyl)(methoxy)dimethylsilane, 6-phenylfulvene, and 6,6-diphenylfulvene, respectively.Without a trapping reagent, the silafulvene undergoes dimerization.
- Nakadaira, Yasuhiro,Sakaba, Hiroyuki,Sakurai, Hideki
-
p. 1071 - 1074
(2007/10/02)
-