The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
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(2008/06/13)
PHOSPHOLIPASE D-CATALYZED TRANS-ALKYLPHOSPHORYLATION: A FACILE ONE-STEP SYNTHESIS OF NUCLEOSIDE 5'-ALKYLPHOSPHATES
Phospholipase D from Streptomyces effectively catalyzed the transfer reaction of the alkylphosphoryl residue from alkylphosphorylcholines to the 5'-hydroxyl group of nucleosides regiospecifically in a two-phase system.Thus, various nucleoside 5'-alkylphosphates could be readily prepared in high yields. KEYWORDS --- trans-alkylphosphorylation; nucleoside 5'-alkylphosphate; phospholipase D; new enzymatic reaction; phosphorylation