- Preparation method of 2-[[tris(hydroxymethyl)methyl]amino]ethanesulfonic acid
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The invention discloses a preparation method of 2-[[tris(hydroxymethyl)methyl]amino]ethanesulfonic acid, which comprises the following steps: dissolving trihydroxymethyl aminomethane and 1,2-dihaloethane in a solvent, heating to reflux reaction while stirring, and controlling the pH value of the solution to be greater than or equal to 7.0 to obtain a first intermediate reaction solution; adding sodium sulfite into the first intermediate reaction solution, and heating to reflux reaction under the action of a catalyst to obtain a second intermediate reaction solution; and cooling and filtering the second intermediate reaction solution, adding cation exchange resin for adsorption, removing the solvent, and crystallizing the liquid to obtain the 2-[[tris(hydroxymethyl)methyl]amino]ethanesulfonic acid. Based on the two-step one-pot method, the reaction yield is high, the post-treatment process is simple and convenient, the product purity is good; meanwhile, the problem of low yield or threewastes caused by use of 2-halogenated ethanesulfonic acid is solved.
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Paragraph 0035-0038
(2021/03/13)
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- Therapeutically active complexes of tetracyclines
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Tri-tetracyclines are complexes of tetracyclines with an amino compound containing per molecule at least a tris (hydroxyalkyl) group and at least a primary or secondary amino group in a molar excess in respect to the tetracycline compound. The complexes have high water solubility and are particularly useful for parenteral administration.
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