Inhibitors of acyl-CoA:Cholesterol O-acyltransferase. 17. Structure-activity relationships of several series of compounds derived from N-chlorosulfonyl isocyanate
Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to N-chlorosulfonyl isocyanate. The (aminosulfonyl)ureas 3-44 were the most potent inhibitors in vitro,
Picard, Joseph A.,O'Brien, Patrick M.,Sliskovic, Drago R.,Anderson, Maureen K.,Bousley, Richard F.,Hamelehle, Katherine L.,Krause, Brian R.,Stanfield, Richard L.
p. 1243 - 1252
(2007/10/03)
SYNTHESES A L'AIDE D'HETEROCUMULENES. 4. Action L'Isocyanate De Chlorosulfonyle Sur les Phenols Encombres
The synthesis of the N-chlorosulfonylcarbamates derived from seven hindered phenols is described, as well as their hydrolysis giving a high yield of the corresponding simple carbamates, the selective substitution of their chlorine atom by the anilino radi
Hedayatullah, Mir,Hugueny, Jean Claude
p. 167 - 172
(2007/10/02)
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