- Preparation method of 4 -tert-butyl phthalonitrile (by machine translation)
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The invention discloses a preparation method of 4 -tert-butylphthalonitrile, and belongs to the technical field of organic synthesis. To the technical scheme, o-xylene and chlorobutane are reacted under the action of catalyst iodine to obtain 4 -tert-butylphthalyl chloride; 4 -tert-butyl phthalic acid is reacted with ammonia solution to obtain 4 -tert-butylphthalamide; 4 -tert-butylphthalamide and dehydrating agent are subjected to dehydration reaction to obtain 4 - 4 - 4 -tert-butylphthalonitrile; and the tert-butylphthalonitrile is obtained through dehydration 4 - 4 . The method has the advantages of mild reaction conditions, high yield, low cost and suitability for industrial production, and is a synthetic method with industrial production value. (by machine translation)
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Paragraph 0023-0024; 0029-0030; 0035-0036
(2020/09/20)
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- An improved synthesis, characterization, and X-ray studies of 5-tert-butyl-3-nitrophthalonitrile
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An improved six-step synthesis of 5-tert-butyl-3-nitrophthalonitrile (1) is described. The title compound and all the intermediates are fully characterized spectroscopically (FT-IR, 1H NMR, 13C NMR, MS). In addition, single-crystal X
- ?apok, ?ukasz,Siudak, Alicja,Nowakowska, Maria
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supporting information
p. 3816 - 3818
(2013/07/05)
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- The synthetic potential of graphite-catalyzed alkylation
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Unmodified graphite is introduced as a mild catalyst for alkylation of aromatic compounds and primary alcohols, applicable when utilization of strong Lewis acids is not feasible. The electrophilic intermediate has a significant carbocationic character and can be formed on a partially rate-limiting step.
- Sereda, Grigoriy A.,Rajpara, Vikul B.,Slaba, Ryan L.
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p. 8351 - 8357
(2008/02/07)
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- Perfluorinated sulfonic acid resin (Nafion-H) catalysed trans-t-butylation of 7-t-butyl-1,3-disubstituted pyrenes; a new route for the preparation of 1,3-disubstituted pyrenes
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The perfluorinated sulfonic acid resin (Nafion-H) catalyst is found to be effective in promoting the trans-t-butylation of 7-t-butyl-1,3-dialkylpyrenes to afford the corresponding 1,3-dialkylpyrenes in good yields.
- Yamato, Takehiko,Hu, Jian-Yong
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p. 762 - 765
(2007/10/03)
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- Alkylation on graphite in the absence of Lewis acids
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Graphite is introduced as a convenient catalyst for alkylation of aromatic compounds and alcohols by benzyl, tertiary alkyl, and secondary alkyl halides in the absence of strong Lewis acids. Primary alkyl halides are not active under the reaction conditions.
- Sereda, Grigoriy A.
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p. 7265 - 7267
(2007/10/03)
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- Poly(5-tert-butyl)benzothiophene: A soluble form of polyisothianaphthene with a large nonlinear optical response
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A soluble form of polybenzothiophene has been produced and chemically characterised. NMR spectroscopy indicates that there is a large quinoidal character contribution to the ground state of the polymer. The third order nonlinear optical properties of the
- Drury, Anna,Burbridge, Simon,Davey, Andrew P.,Blau, Werner J.
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p. 2353 - 2355
(2007/10/03)
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- Aromatic compounds and their use in perfumery
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The compounds of formula STR1 wherein symbol X represents a --CHO group or an acetal group of formula STR2 symbols R', taken separately, represent each a C1 to C4, linear or branched, saturated or unsaturated, hydrocarbon radical or, taken together, represent a C1 to C4 alkylene radical, which may be substituted, and symbol R represents a hydrogen atom or a methyl radical, are useful as perfuming ingredients for the preparation of perfuming compositions and perfumed articles, to which they impart floral type notes.
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- Selective alkylation of xylenes by alcohols on zeolite catalysts
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The peculiarities of catalytic performance of crystalline aluminosilicates of different types and compositions (X, Y including dealuminated Y′, mordenite, pentasil ZSM-5), as well as of amorphous aluminosilicate catalyst in conversion of xylene + alcohol mixtures were studied. New data were obtained for alkylation of o-xylene with tert-butyl alcohol, concerning controlling the selectivity and stability of the zeolite catalysts in reactions proceeding with the participation of water, including the water evolved during the reaction, in particular by controlling the acidic properties and hydrophobycity of the zeolites. A catalyst ensuring production of 1,2-dimethyl-4-tert-butylbenzene (DMTBB) with a 94% yield and selectivity of alcohol conversion to the target product of 94-97% was developed. The catalyst can be used as the basis for a high-performance and environmentally safe method for the synthesis of DMTBB. The catalysts developed can be also used for selective alkylation of o-xylene by C3-C5 alcohols and for alkylation of m-xylene by tert-butyl alcohol.
- Isakov,Minachev,Kalinin,Isakova
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p. 2763 - 2768
(2007/10/03)
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- REACTION OF AROMATIC HYDROCARBONS WITH 2-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)ETHYL ACETATE AT HETEROPOLY ACIDS
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When 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethyl acetate is heated with aromatic hydrocarbons at the solid heteropoly acid (H3PW12O4/SiO2), the following three types of reactions take place simultaneously: de-tert-butylation and condensation of the phenols with the formation of 1,2-diarylethanes and tert-butylation of the aromatic hydrocarbons.
- Titova, T. F.,Krysin, A. P.
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p. 1593 - 1596
(2007/10/03)
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- Synthesis of Tetrakis(4-tert-butylbenzo)porphin and its Metal Complexes
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The condensation of 4-tert-butylphthalimide with sodium and zinc acetates leads to the zinc complex of tetrakis(4-tert-butylbenzo)porphin, which forms the free ligand under the influence of boiling trifluoroacetic acid.A series of metalloporphyrins were obtained from tetrakis(4-tert-butylbenzo)porphin and metal acetates.
- Mamardashvili, N. Zh.,Semeikin, A. S.,Golubchikov, O. A.
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p. 818 - 821
(2007/10/02)
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- Preparation of (1,2,3)cyclophanes by Reaction of 2,8-Di-tert-butyl-4,6-bis(chloromethyl)dibenzocycloheptene with Aromatic Compounds in the Presence of TiCl4
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The reactions of 2,8-di-tert-butyl-4,6-bis(chloromethyl)dibenzocycloheptene with benzene, toluene, o-xylene, and p-dimethoxybenzene afforded the corresponding de-trans-tert-butylated benzo(1,2,3)cyclophane derivatives, while the reactions with
- Tashiro, Masashi,Furusawa, Takashi,Tsuge, Akihiko,Mataka, Shuntaro,Yamato, Takehiko
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p. 834 - 844
(2007/10/02)
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- Perfluorooctanesulfonic acid catalyzed Friedel-Crafts alkylation with alkyl halides
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A new procedure to prepare superacid perfluorooctanesulfonic acid (POSA) is reported. POSA catalyzed Friedel-Crafts alkylation of aromatic compounds with alkyl halides in liquid-phase reactions. Alkylation gave higher total yields than the corresponding reactions with Nafion-H, without the need of any complex decomposition or work-up. The reactions do not need to be carried out under absolutely anhydrous condition. The catalyst POSA can be easily separated from the reaction mixture and reused or recovered. The reactivity of the alkylation reagents and the mechanism of the reaction are discussed.
- Fu,He,Lei,Luo
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p. 1273 - 1279
(2007/10/02)
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- CHLORINATION OF 4-tert-ALKYL-o-XYLENES
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The chlorination of 4-tert-butyl-o-xylene and tert-amyl-o-xylene with chlorine and sulfuryl chloride leads to the formation of the products from substitution of the hydrogen atoms at positions 3, 5, and 6 and the tert-alkyl groups at position 4 of the benzene ring.
- Pozdnyakovich, Yu. V.,Borodovitsyn, V. V.,Shein, S. M.
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p. 138 - 141
(2007/10/02)
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- Aromatic Substitution in the Gas Phase. Alkylation of Arenes by C4H9+ Ions from the Protonation of C4 Alkenes and Cycloalkanes with Gaseous Bronsted Acids
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Use of a reactive aromatic substrate (o-xylene) to sample the isomeric population of the butyl ions from the gas-phase protonation of the C4H8 hydrocarbons shows that the primary product from linear olefins and methylcyclopropane is the s-butyl ion, or at least an s-butylating charged species displaying a positional selectivity very similar to that measured for the thermal s-butyl cations obtained from n-butane.A fraction of the primary C4H9+ ions isomerizes to the most stable tertiary structure, to an extent which depends, inter alia, on the exothermicity of the proton transfer process.Protonation of cyclobutane gives an alkylating reagent whose s-butylation/t-butylation ratio and positional selectivity set it apart from the C4H9+ reagents obtained from the other C4H8 hydrocarbons, suggesting the intervention of a different electrophile, conceivably protonated cyclobutane.Finally, protonation of isobutene yields exclusively a t-butyl ion that does not isomerize despite the large exothermicity of its formation.
- Cacace, Fulvio,Ciranni, Giovanna,Giacomello, Pierluigi
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p. 1373 - 1378
(2007/10/02)
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