Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents
A novel series of potent pyrazolo[1,5-a]pyridine inhibitors of herpes simplex virus 1 replication have been identified. Several complimentary synthetic methods were developed to allow facile access to a diverse set of analogs from common late stage interm
Johns, Brian A.,Gudmundsson, Kristjan S.,Turner, Elizabeth M.,Allen, Scott H.,Samano, Vicente A.,Ray, John A.,Freeman, George A.,Boyd Jr., F. Leslie,Sexton, Connie J.,Selleseth, Dean W.,Creech, Katrina L.,Moniri, Kelly R.