PROCESS FOR PREPARING BRANCHED RIBONUCLEOSIDES FROM 1, 2-ANHYDRORIBOFURANOSE INTERMEDIATES
A process is provided for the preparation of branched-chain ribonucleosides of formula (I) from the 1,2- anhydro derivatives of fomula (II). The compounds of fomula (I) are inhibitors of HCV polymerase useful in the treatment of HCV infection.
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Page 11
(2008/06/13)
Practical synthesis of a potent hepatitis C virus RNA replication inhibitor
A practical, efficient synthesis of 1, a hepatitis C virus RNA replication inhibitor, is described. Starting with the inexpensive diacetone glucose, the 12-step synthesis features a novel stereoselective rearrangement to prepare the key crystalline furanose diol intermediate. This is followed by a highly selective glycosidation to couple the C-2 branched furanose epoxide with deazapurine.
Bio, Matthew M.,Xu, Feng,Waters, Marjorie,Williams, J. Michael,Savary, Kimberly A.,Cowden, Cameron J.,Yang, Chunhua,Buck, Elizabeth,Song, Zhiguo J.,Tschaen, David M.,Volante,Reamer, Robert A.,Grabowski, Edward J. J.
p. 6257 - 6266
(2007/10/03)
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