- Transition-metal-catalyzed synthesis of aspergillide B: An alkyne addition strategy
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A catalytic enantioselective formal total synthesis of aspergillide B is reported. This linchpin synthesis was enabled by the development of new conditions for Zn-ProPhenol catalyzed asymmetric alkyne addition. This reaction was used in conjunction with ruthenium-catalyzed trans-hydrosilylation to affect the rapid construction of a late-stage synthetic intermediate of aspergillide B to complete a formal synthesis of aspergillide B in a highly efficient manner.
- Trost, Barry M.,Bartlett, Mark J.
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supporting information; experimental part
p. 1322 - 1325
(2012/04/23)
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- Synthesis of (5Z,8Z,11Z,14Z)-18- and 19-azidoeicosa-5,8,11,14-tetraenoic acids and their [5,6,8,9,11,12,14,15-3H8]-analogues through a common synthetic route
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Total synthesis of (5Z,8Z,11Z,14Z)-18- and 19-azidoeicosa-5,8,11,14- tetraenoic acids and their [5,6,8,9,11,12,14,15-3H 8]-analogues via the corresponding p-toluenesulphonates is reported. This synthetic approach allows the preparati
- Romanov, Stepan G.,Ivanov, Igor V.,Shevchenko, Valery P.,Nagaev, Igor Yu.,Pushkov, Alexandr A.,Myasoedov, Nikolai F.,Myagkova, Galina I.,Kuhn, Hartmut
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p. 117 - 126
(2007/10/03)
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