- MK2 INHIBITORS AND USES THEREOF
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The present invention provides compounds, compositions thereof, and methods of using the same.
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Paragraph 001105
(2014/10/03)
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- PHENYLETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES
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The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
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- PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES
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The present invention relates to novel compounds of formula (I),to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
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Page/Page column 81-82
(2010/02/07)
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- Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders
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4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment of neurodegenerative disorders. 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, other than carboxy or C 1-6 alkoxycarbonyl, are novel compounds, as also are compounds of formula II STR1 wherein R 2 represents carboxy or a group convertible thereto in vivo, R 6 is hydrogen and R 5 and R 7 represent C 1-6 alkyl or halogen, provided that R 5 and R 7 are not simultaneously chlorine or simultaneously bromine; a process for preparing the novel compounds is described, as also are pharmaceutical compositions containing the novel compounds.
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- Copper(I)-Induced Halogen-Hydrogen Exchange of 2-Halogenoanilines
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The copper(I)-induced halogen-hydrogen exchange in the 2-position of 2,3-dibromoaniline, 2,3-dibromo-5-methylaniline, 2,3-dibromo-5-chloroaniline and 3-bromo-2-iodoaniline has been studied in acetic acid, ethanol and chlorobenzene media with a hydrochloric acid content of 0.56 mol dm-3.The CuX32- complexes used in the reduction reaction are (CH3Ph3P+)2CuBr32-, (CH3PH3P+)2CuI32-, (NH4+)2CuBr32- and (NH4+)2CuCl32-. (C4H9)4N+ CuCl2- and NH4+ CuBr2- have also been tested in the same media.The reduction rate increases with the size of the Cu(I)-complex.
- Liedholm, Brita
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p. 701 - 705
(2007/10/02)
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- The Kinetics of the Reactions of Picryl Chloride with Some Substituted Anilines. Part 5.
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Arrhenius parameters have been measured for the reactions of picryl chloride with the following substituted anilines in acetonitrile: 3-amino- and 3-methyl-aniline, 3-amino-5-nitroaniline, 3-fluoro-5-methylsulphonylaniline, 3-X-5-methylanilines (X=NO2, OMe, CH3, F, Cl, Br, or I) and 3,5-X2-anilines (X = F, Cl, Br, or I).A total of 33 3,5-disubstituted anilines have now been examined for the additivity of substituent effects on the free energy of activation, and it has been shown that with the exception of 3-amino-5-nitroaniline this hypothesis reproduces experimental rate constants within a factor of 2.A rationalization is proposed for the deviations that occur in some cases when more stringent criteria of additivity are used.
- Emokpae, Thomas A.,Eguavoen, Osa,Hirst, Jack
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p. 829 - 831
(2007/10/02)
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