- Metallation Reactions. XVIII. Regioselective metallation of (alkylthio)benzenes by superbases
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(Alkylthio)benzenes were monometallated at the alpha position by a stoichiometric mixture of butyllithium and potassium t-butoxide and bimetallated at both the alpha and the ortho positions by two equivalents of the same reagent.
- Cabiddu, S.,Fattuoni, C.,Floris, C.,Gelli, G.,Melis, S.
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p. 197 - 202
(2007/10/02)
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- Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor
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3-Hydroxybenzo[b]thiophene derivatives, such as 2-aralkyl, 2-alkyl and 2-alkenyl-3-hydroxybenzo[b]-thiophenes, were prepared by, among other methods, ring closure of 2-(2-carboxy-phenylthio)-α-substituted acetic acids. These compounds are found to be useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases, cardiovascular disorders, psoriasis, inflammatory diseases and other prostaglandin and/or leukotriene mediated diseases.
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