Cyclopropane Derivatives, 2. - Self-Acylation of α-Alkyl-γ-lactones To Give Bis(1-alkylcyclopropyl)ketones via Spiroacetals
High-yield synthetic ways are recommended for the title lactones 1.The coupling of two 2-alkyl-4-butanolides is possible in an inter-(1b, c) or intramolecular fashion (4c) to give spiroacetals 8 or 9, respectively, in the absence of hindering substituents.Symmetrically substituted bis(1-alkylcyclopropyl)ketones 12 and 13 may be prepared by acidic cleavage of those spiroacetals lacking 2,7-substituents.
Boehrer, Gerald,Knorr, Rudolf,Boehrer, Petra
p. 2161 - 2166
(2007/10/02)
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