- Preparation method of edaravone related substances
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The invention belongs to the field of chemical medicines and particularly relates to a preparation method of an edaravone dimer and an edaravone trimer. The preparation method includes the steps of: adding edaravone to an organic solvent, adding a carbonate and performing a reaction under a high-pressure microwave condition to simultaneously produce the edaravone dimer and edaravone trimer. The preparation method is short in reaction time, employs environment-friendly solvent, has low damage on instrument, greatly reduces reaction time and saves time cost, can simultaneously produce the two edaravone related substances and improves utilization rate of raw materials.
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Paragraph 0027-0028; 0029; 0030; 0031; 0032; 0033; 0034
(2017/09/26)
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- Detection and Treatment of Schizophrenia
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The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.
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- New synthesis of pyrazolo[3,4-b][1,4,5]benzothiadiazepine, -[1,4,5]benzoxadiazepine, -[1,4,5]benzotriazepine and pyrazolo[3,4-b]quinoxaline derivatives
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New pyrazolo[3,4-b][1,4,5]benzothiadiazepine and its analogues 3 have been obtained by reaction of 4-nitrosopyrazoles 1 with 2-aminothiophenol 2a and its analogues 2b,c. Under fused conditions, dipyrazolyl derivatives 7a was obtained with a trace amount of quinoxaline 5a. On the other hand, 5b and 7b were obtained in equal amounts. A proposed pathway is presented.
- El-Rady, Eman A.
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p. 859 - 862
(2007/10/03)
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- Investigations on the Reaction of Pyrazolone Azomethine Dyes with 2-Pyrazolin-5-one-Derivatives
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The reaction between pyrazolone azomethine dyes 1 and different 2-pyrazolin-5-ones 2 was investigated.Among the reaction products compounds 5 > was isolated, which hitherto was unknown as a product of this reaction.A new reaction pathway is proposed.
- Kucybala, Z.,Gaca, J.
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p. 435 - 439
(2007/10/02)
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- Investigation of Reactions of Pyrazolin-Azomethin Dyes with 2-Pyrazolin-5-one
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The pyrazolin-azomethin dyes (3a-d) from 1-phenyl-3-methyl-2-pyrazolin-5-one and various photographic developers have been obtained.The reactions of decolourization of dyes during the 3-methyl-1-phenyl-2-pyrazolin-5-one action was investigated.We ascertained that the substituent changes in the developer had not only the influence on decolourization rate but they also had influence on the order change of the reaction.The various solvents had the same influence on the reaction rate of decolourization.
- Gaca, J.,Kozlowski, K.,Trzcinska, M.,Kucybala, Z.
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p. 149 - 155
(2007/10/02)
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- Process for preparing fiber-reactive phthalocyanine azo dyes
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Process for preparing fiber-reactive water-soluble phthalocyanine azo dyes, using the following conversion stages STR1 followed by the diazonium coupling of the fiber-reactive group to the pyrazole ring. The novel intermediates are desirable products.
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- Process for preparing 2,5-dimethyl-3-(2H)-furanone
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There is disclosed a simple, economical process for preparing 2,5-dimethyl-3-(2H)-furanone by hydrolysis of the dimer of diacetyl at a temperature of 20°C to 120°C and in the presence of an acid, mineral or organic, or of a cationic resin, with elimination of a acetic acid.
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