- Antioxidant activity of some ascorbic and cinnamic acids derivatives
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Some 4-benzoyl 3-hydroxy furan-2 (5H) ones (3a-d) and 2-amino 3-hydroxymethyl 4-aryl 4-oxo 2-butenoic acids (4a-h) have been synthesized. Compound 3c with an isobutyl substituent in the 5-position of the furan ring was the most effective (IC50 = 8.69 x 10-4 M) in scavenging the superoxide anion. In vivo, 3c was also protective against reperfusion injury.
- Point, Dominique,Coudert, Pascal,Leal, Fernand,Rubat, Catherine,Sautou-Miranda, Valerie,Chopineau, Jean,Couquelet, Jacques
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- Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of β-Substituted α-Oxobutyrolactones
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A concise and effective ruthenium-catalyzed asymmetric transfer hydrogenation of β-substituted α-oxobutyrolactones has been developed, delivering a series of cis-β-substituted α-hydroxybutyrolactone derivatives with excellent yields, enantioselectivities,
- Hu, Zi-Qi,Li, Xiang,Liu, Li-Xia,Yu, Chang-Bin,Zhou, Yong-Gui
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supporting information
p. 17453 - 17461
(2021/11/18)
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- Substituted γ-Lactones. XXX (1). Reactions of α-Keto-β-Substituted-γ-butyrolactones with Diamines
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The condensation reaction between α-keto-β-aroyl (or acyl)-γ-butyrolactones, 4a-4e and o-phenylenediamine or 2,3-diaminonaphthalene leads under retrograde aldol condensation involving loss of formaldehyde to formation of 3-substituted-3,4-dihydro-2(1H)quinoxalinones or benzoquinoxalinones, 7a-7g, respectively as a new convenient synthesis of this type of heterocyclic systems.The reaction of type 4 compound with 4,5-diaminopyrimidine, 8, was found to proceed differently. 2--4-oxo-3-(hydroxymethyl)-4-phenyl-2-butenoic acid 9 was the only product formed when the reaction between 4a and 8 was run in ethanol.The same reaction in glacial acetic acid proceeds with loss of formaldehyde, to afford 7-phenacylidene-7,8-dihydro-6(1H)-pteridinone 10.The reaction between type 4 compounds and ethylenediamine or 1,4-phenylenediamine leads to the formation of the bis-condensation products 13-15, respectively.
- Amer, Adel,Ventura, Montserrat,Zimmer, Hans
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p. 359 - 364
(2007/10/02)
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