Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter
Methamphetamine, a human vesicular monoamine transporter 2 (VMAT2) substrate, releases dopamine, serotonin, and norepinephrine from vesicles into the cytosol of presynaptic neurons and induces reverse transport by the monoamine transporters to increase ex
Provencher, Brian A.,Eshleman, Amy J.,Johnson, Robert A.,Shi, Xiao,Kryatova, Olga,Nelson, Jared,Tian, Jianhua,Gonzalez, Mario,Meltzer, Peter C.,Janowsky, Aaron
p. 9121 - 9131
(2018/10/20)
VMAT INHIBITORY COMPOUNDS
Disclosed herein are compounds that bind to the vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions comprising those compounds, and methods of treatment using said compounds and pharmaceutical compositions.
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Paragraph 0211-0214
(2016/04/01)
Derives alkyles et aryles de l'acide nipecotique: synthese et appreciation de l'activite inhibitrice de la capture du GABA en fonction de parametres conformationnels et de biodisponibilite
Alkyl and aryl derivatives of nipecotic acid: synthesis and inhibition of GABA uptake as a function of conformational parameters and bioavailability.Analogs of nipecotic acid, substituted at positions 2, 3, 4, 5, or 6 with a methyl or phenyl group were pr