- Dirhodium-Catalyzed Enantioselective B?H Bond Insertion of gem-Diaryl Carbenes: Efficient Access to gem-Diarylmethine Boranes
-
The scarcity of reliable methods for synthesizing chiral gem-diarylmethine borons limits their applications. Herein, we report a method for highly enantioselective dirhodium-catalyzed B?H bond insertion reactions with diaryl diazomethanes as carbene precursors. These reactions afforded chiral gem-diarylmethine borane compounds in high yield (up to 99 % yield), high activity (turnover numbers up to 14 300), high enantioselectivity (up to 99 % ee) and showed unprecedented broad functional group tolerance. The borane compounds synthesized by this method could be efficiently transformed into diaryl methanol, diaryl methyl amine, and triaryl methane derivatives with good stereospecificity. Mechanistic studies suggested that the borane adduct coordinated to the rhodium catalyst and thus interfered with decomposition of the diazomethane, and that insertion of a rhodium carbene (generated from the diaryl diazomethane) into the B?H bond was most likely the rate-determining step.
- Huang, Ming-Yao,Li, Xiao-Yu,Su, Yu-Xuan,Yang, Liang-Liang,Zhao, Yu-Tao,Zhu, Shou-Fei
-
supporting information
p. 24214 - 24219
(2021/10/07)
-
- Dimethomorph hapten, and preparation method and application thereof
-
The invention relates to the technical field of biology, and discloses a dimethomorph hapten, and a preparation method and an application thereof. The dimethomorph hapten reserves the chemical structure of dimethomorph to the greatest extent, a nitrogen-c
- -
-
Paragraph 0010; 0037-0038
(2020/06/02)
-
- Recyclable polyetheretherketone fiber-supported N-heterocyclic carbene catalysts for nucleophilic acylation of fluorobenzenes
-
We report for the first time a novel support of polyetheretherketone fiber for the synthesis of recyclable N-heterocyclic carbene (NHC) catalysts. The fiber catalysts were verified in nucleophilic acylation of fluorobenzenes with superior catalytic activities, and successfully recycled by a tiny pair of tweezers over 21 cycles with minimal loss of performance.
- Shi, Xian-Lei,Sun, Benyu,Hu, Qianqian,Liu, Kun,Li, Pengyu,Wang, Juanjuan
-
supporting information
p. 11390 - 11393
(2020/10/12)
-
- Pd-Catalyzed Suzuki–Miyaura Cross-Coupling of Arylboronic Acids and α-Iminonitriles through C–CN Bond Activation
-
A Pd-catalyzed Suzuki–Miyaura cross-coupling reaction between arylboronic acids and α-iminonitriles has been developed. The reaction proceeds through selective activation of the C–CN bond, tolerates a wide range of substituents, and delivers the versatile ketone products in moderate to excellent yields.
- Liu, Kui,Tao, Shou-Wei,Qian, Chun,Zhu, Yong-Ming
-
supporting information
p. 4769 - 4775
(2018/09/06)
-
- α-Chlorobenzylation of Nitroarenes via Vicarious Nucleophilic Substitution with Benzylidene Dichloride: Umpolung of the Friedel-Crafts Reaction
-
Readily available α,α-dichlorotoluenes enter a vicarious nucleophilic substitution (VNS) reaction with electron-deficient arenes to give α-chlorobenzylated nitrobenzenes, as well as six- and five-membered heterocycles. Oxidation of the initially formed α-chlorobenzylic carbanions instead of protonation results in formation of diaryl ketones, providing a means for overall nucleophilic C-H benzoylation of electron-deficient aromatic rings. Alternatively, benzoylated nitroarenes can be obtained via the reaction of isolated α-chlorodiarylmethanes with sodium azide.
- Brze?kiewicz, Jakub,Loska, Rafa?,Makosza, Mieczys?aw
-
p. 8499 - 8508
(2018/06/25)
-
- Transition-Metal-Free Regiospecific Aroylation of Nitroarenes Using Ethyl Arylacetates at Room Temperature
-
A novel regiospecific C(sp3)-C(sp2) coupling between ethyl arylacetates and nitroarenes has been developed to deliver biaryl ketones in excellent yields. The protocol is metal-free, mild, and compatible with a number of functional groups on both of the reacting partners.
- Kumar, Promod,Sharma, Anup Kumar,Guntreddi, Tirumaleswararao,Singh, Rahul,Singh, Krishna Nand
-
supporting information
p. 744 - 747
(2018/02/09)
-
- Aerobic oxidative acylation of nitroarenes with arylacetic esters under mild conditions: Facile access to diarylketones
-
A facile and regioselective base-mediated aerobic oxidative acylation of nitroarenes to access diarylketones under mild conditions has been developed. It features the use of bench-stable and readily available arylacetates as acyl surrogates, and the absence of transition-metals and synthetic oxidants. This protocol involves a cascade CDC/oxidative decarboxylation process.
- Li, Jiang-Sheng,Yang, Qian,Yang, Fan,Chen, Guo-Qin,Li, Zhi-Wei,Kuang, Yin-Jie,Zhang, Wei-Jing,Huang, Peng-Mian
-
p. 140 - 145
(2017/12/27)
-
- Diarylketone preparation method
-
The invention discloses a diarylketone preparation method. According to the method, substituted nitrobenzene and aromatic acetic ester are dissolved in an organic solvent, alkali is added, the mixture is subjected to a reaction in the air or oxygen atmosphere at the temperature of 10-60 DEG C for 0.5-24 h, and diarylketone is obtained; the mole ratio of substituted nitrobenzene to aromatic acetic ester is (0.5:1)-(5:1), and the mole ratio of alkali to aromatic acetic ester is (1:1)-(5:1). The method overcomes defects caused by the adoption of strong acid or expensive metal reagents or strong oxidizers and the like in the prior art and has the advantages as follows: 1) with air as an oxidizer, use of strong or expensive chemical oxidizers is avoided; 2) no transition metal catalysts are used, so that the condition that heavy metal ions are left in a product is avoided; 3) without inductive groups, surplus steps of introduction of the inductive groups and removal of the inductive groups are avoided; 4) acylation of ortho positions or para positions of nitro-aromatic compounds is directly realized, which cannot be realized with a classic Friedel-Crafts acylation method. The synthesis method plays an important role in preparing diarylketone, particularly industrial production of acylation products of ortho positions or para positions of the nitro-aromatic compounds.
- -
-
Paragraph 0019; 0029
(2017/09/05)
-
- Transition metal-free Suzuki type cross-coupling reaction for the synthesis of dissymmetric ketones
-
A simple, efficient and metal-free route for the synthesis of dissymmetric ketones through Suzuki type cross-coupling reaction has been established. This strategy signifies an attractive, cost-effective and operationally convenient tool for the synthesis of a wide range of dissymmetric ketones. Although conventional routes for the synthesis of ketones have been widely used, the potential challenge with these methods is functional group tolerance. The reported metal-free method represents a reaction with moderate functional group tolerance. The procedure is operationally convenient and shows broad substrate scope with good to excellent product yields.
- Jadhav, Sanjay,Rashinkar, Gajanan,Salunkhe, Rajashri,Kumbhar, Arjun
-
supporting information
p. 3201 - 3204
(2017/07/27)
-
- A Zwitterionic Palladium(II) Complex as a Precatalyst for Neat-Water-Mediated Cross-Coupling Reactions of Heteroaryl, Benzyl, and Aryl Acid Chlorides with Organoboron Reagents
-
The Suzuki–Miyaura cross-coupling (SMC) reactions of several heteroaryl chlorides, benzyl chlorides, and aryl acid chlorides with (hetero)arylboron reagents have been investigated in the presence of [Pd(HL1)(PPh3)Cl2] (I) [HL1 = 3-[(2,6-diisopropylphenyl)-1-imidazolio]-2-quinoxalinide] as catalyst and K2CO3 as base in neat water. The synthesis of the heterocycle-containing biaryls required the addition of 2 mol-% of a phosphine ligand (PPh3 or X-Phos). A combination of more than 115 substrates were screened and it was found that I is a versatile catalyst that can produce heterocycle-containing biaryls, diarylmethanes, and benzophenones in moderate-to-excellent yields.
- Ramakrishna, Visannagari,Rani, Morla Jhansi,Reddy, Nareddula Dastagiri
-
p. 7238 - 7255
(2018/01/01)
-
- Iron-catalyzed carbonylation of aryl halides with arylborons using stoichiometric chloroform as the carbon monoxide source
-
A general iron-catalyzed carbonylative Suzuki-Miyaura coupling of aryl halides with arylborons is reported, using stoichiometric CHCl3 as the CO source. The high efficiency, economy, selectivity, and operational simplicity of this transformation make this method a valuable tool in organic synthesis. Importantly, the presented strategy allows effective 13C labeling simply by using the commercially available 13C-labeled CHCl3. On the basis of the initial mechanistic exploration, an aryl radical intermediate is proposed in the present carbonylation process.
- Zhao, Hongyuan,Du, Hongyan,Yuan, Xiaorong,Wang, Tianjiao,Han, Wei
-
supporting information
p. 5782 - 5787
(2016/11/06)
-
- Phosphine-Free, Heterogeneous Palladium-Catalyzed Atom-Efficient Carbonylative Cross-Coupling of Triarylbismuths with Aryl Iodides: Synthesis of Biaryl Ketones
-
A novel and highly efficient heterogeneous palladium-catalyzed carbonylative cross-coupling of aryl iodides with triarylbismuths has been developed that proceeds smoothly at atmospheric CO pressure and provides a general and powerful tool for the preparation of various valuable biaryl ketones with high atom economy, good to excellent yield, and recyclability of the catalyst. The reaction is the first example of Pd-catalyzed carbonylative cross-coupling for the construction of biaryl ketones using triarylbismuths as substrates.
- Hao, Wenyan,Liu, Haiyi,Yin, Lin,Cai, Mingzhong
-
p. 4244 - 4251
(2016/06/09)
-
- QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS
-
The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, in the treatment of disorders
- -
-
Paragraph 0513
(2015/09/23)
-
- QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS
-
The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, in the treatment of disorders
- -
-
Paragraph 0509
(2015/09/28)
-
- METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T
-
The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
- -
-
Page/Page column 82
(2015/05/05)
-
- ARYL-AND HETEROARYL-SUBSTITUTED BENZENE DERIVATIVES AS MODULATORS OF PI3-KINASE SIGNALLING PATHWAYS
-
The present disclosure relates to certain aryl- or heteroaryl-substituted benzene derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.
- -
-
Paragraph 0203
(2014/03/21)
-
- A phosphane-free, atom-efficient cross-coupling reaction of triarylbismuths with acyl chlorides catalyzed by MCM-41-immobilized palladium complex
-
The first phosphane-free, heterogeneous, atom-efficient cross-coupling reaction of triarylbismuths and acyl chlorides was achieved in N-methylpyrrolidone (NMP) with Bu3N as the base at 80 °C in the presence of 1.5 mol-% MCM-41-immobilized bidentate nitrogen palladium complex [MCM-41-2N-Pd(OAc)2, MCM = mobile crystalline material] to yield a variety of unsymmetrical biaryl ketones in good to excellent yields. This heterogeneous palladium catalyst exhibited a high activity, which was similar to that of Pd(PPh3)4. The catalyst can be recovered by a simple filtration of the reaction solution and recycled in at least 10 consecutive trials without any decrease in activity. Our system not only avoids the use of phosphane ligands, but also solves the basic problem of palladium catalyst recovery and reuse. The first phosphane-free, heterogeneous, atom-efficient cross-coupling reaction of triarylbismuth compounds and acyl chlorides was achieved in N-methylpyrrolidone with Bu3N as the base at 80 °C in the presence of 1.5 mol-% MCM-41-immobilized bidentate nitrogen palladium complex [MCM-41-2N-Pd(OAc)2] to yield a variety of unsymmetrical biaryl ketones in good to excellent yields. Copyright
- Zhao, Hong,Yin, Lin,Cai, Mingzhong
-
p. 1337 - 1345
(2013/04/10)
-
- Radical-forming polyamides for self-decontamination coatings
-
Design and synthesis of thermally stable polyamides with improved solubility based on an asymmetrical aromatic diamine containing phenoxy substituted benzophenone segment was the main objective of this work. These polymers were easily soluble at room temperature in polar aprotic solvents and even in less polar solvents, such as tetrahydrofuran. The polymers showed excellent thermal stability, up to 385°C, and exhibited glass transition in the range of 225-256°C. All the polymers emitted an intense blue light upon irradiation with UV light, due to the emission from the benzophenone chromophore. The free-standing films having the thickness in the range of tens of micrometers obtained from these polymers were flexible, tough, and maintained their integrity after repeated bendings. To investigate the radical-forming ability of the polyamides for decomposing surrounding harmful materials, degradation of methylene blue by the polymer films was studied.
- Damaceanu, Mariana-Dana,Rusu, Radu-Dan,Bruma, Maria
-
p. 799 - 806
(2013/05/09)
-
- Synthesis, molecular modelling and biological evaluation of 4-amino-2(1H)-quinazolinone and 2,4(1H,3H)-quinazolidone derivatives as antitumor agents
-
A series of 6-benzoyl-, 6-arylthio- and 6-arylsulfonyl-4-amino-2(1H)- quinazolinones and -2,4(1H,3H)-quinazolinediones were prepared. They were evaluated in vitro for their cytotoxicity against the NCI-60 cancer cell lines. A series of 6-benzoyl-, 6-arylthio- and 6-arylsulfonyl-4-amino-2(1H)- quinazolinones and -2,4(1H,3H)-quinazolinediones were prepared. They were evaluated in vitro for their cytotoxicity against the NCI-60 cancer cell lines. Copyright
- Richter, Stephanie,Gioffreda, Barbara
-
experimental part
p. 810 - 820
(2012/03/08)
-
- A phosphine-free carbonylative cross-coupling reaction of aryl iodides with arylboronic acids catalyzed by immobilization of palladium in MCM-41
-
The phosphine-free heterogeneous carbonylative cross-coupling of aryl iodides with arylboronic acids under an atmospheric pressure of carbon monoxide was achieved in anisole at 80 °C in the presence of a 3-(2-aminoethylamino) propyl-functionalized MCM-41-immobilized palladium(ii) complex [MCM-41-2N-Pd(ii)], yielding a variety of unsymmetrical biaryl ketones in good to high yield. This heterogeneous palladium catalyst exhibited higher activity and selectivity than PdCl2(PPh3)2, can be recovered and recycled by a simple filtration of the reaction solution, and used for at least 10 consecutive trials without any decrease in activity. Our system not only avoids the use of phosphine ligands, but also solves the basic problem of palladium catalyst recovery and reuse.
- Cai, Mingzhong,Peng, Jian,Hao, Wenyan,Ding, Guodong
-
experimental part
p. 190 - 196
(2011/03/20)
-
- Copper-catalyzed arylation of arylboronic acids with aldehydes
-
A novel copper-catalyzed arylation of arylboronic acids with aldehydes under oxygen atmosphere was achieved in the presence of Cu(OTf)2 and Xantphos, affording diaryl ketone derivatives in moderate to good yields. The efficiency of this reaction was demonstrated by the compatibility with fluoro, bromo, chloro, nitro, -methylsulfonyl, and trifluoromethyl groups. Georg Thieme Verlag Stuttgart ? New York.
- Zheng, Hanmei,Ding, Jinchang,Chen, Jiuxi,Liu, Miaochang,Gao, Wenxia,Wu, Huayue
-
experimental part
p. 1626 - 1630
(2011/08/03)
-
- NOVEL ACYLAMINOBENZAMIDE DERIVATIVES
-
The present invention relates to novel Acylaminobenzamide derivatives represented by the following formula (I) and use thereof as pesticides: wherein V represents an aromatic ring group of V1 to V5 described in the detailed description, Q represents an ar
- -
-
Page/Page column 79-80
(2010/04/03)
-
- Trans-chelating ligands in palladium-catalyzed carbonylative coupling and methoxycarbonylation of aryl halides
-
The manuscript describes the use of a trans-chelated palladium complex derived from 1,8-bis-(4-(diphenylphosphino)phenyl)anthracene (1) and p-TolPdI(TMEDA) as a precatalyst in carbonylative Suzuki coupling and methoxycarbonylation of aryl iodides and bromides. The catalyst is active in 0.01-1 mol% loading and demonstrates highly selective transformations. The selectivity is attributed to the unique structural features of the trans-chelating ligands.
- Kaganovsky, Luba,Gelman, Dmitri,Rueck-Braun, Karola
-
experimental part
p. 260 - 266
(2010/03/26)
-
- One-pot synthesis of diaryl ketones from aldehydes via palladium-catalyzed reaction with aryl boronic acids
-
A Pd-catalyzed coupling-type reaction of aldehydes and organoboronic acids was achieved in the presence of P(1-nap)3, using Cs2CO3 in toluene, providing diaryl ketones with yields ranged from moderate to excellent. The efficiency of this reaction was demonstrated by the compatibility with nitro, cyano, trifluoromethyl, fluoro and chloro groups. Moreover, the rigorous exclusion of air/moisture is not required in these transformations.
- Qin, Changming,Chen, Jiuxi,Wu, Huayue,Cheng, Jiang,Zhang, Qiang,Zuo, Bing,Su, Weike,Ding, Jinchang
-
p. 1884 - 1888
(2008/09/18)
-
- N-heterocyclic carbene-catalyzed nucleophilic aroylation of fluorobenzenes
-
(Chemical Equation Presented) In N-heterocyclic carbene (NHCs) catalyzed nucleophilic substitution of fluorobenzenes, fluoro groups are replaced by aroyl groups, which are derived from aromatic aldehydes. 1,3,4,5-Tetramethylimidazol- 2-ylidene is found to be an efficient catalyst. The catalyst loading can be reduced to 1 mol % without a significant decrease in the product yields. Polysubstituted benzophenones are synthesized from fluorobenzenes and benzaldehydes by the NHC-catalyzed aroylation.
- Suzuki, Yumiko,Ota, Shinya,Fukuta, Yoshinori,Ueda, Yuki,Sato, Masayuki
-
p. 2420 - 2423
(2008/09/19)
-
- Streamlined processes for the synthesis of a farnesyl transferase inhibitor drug candidate
-
As part of a fast-paced oncology program, quinolinone 1 was discovered and developed as a potent inhibitor of farnesyl transferase for the treatment of cancer. The initial synthesis, which suffered from a lengthy linear sequence and a late-stage chromatog
- Andresen, Brian M.,Couturier, Michel,Cronin, Brian,D'Occhio, Michael,Ewing, Marcus D.,Guinn, Mark,Hawkins, Joel M.,Jasys, V. John,LaGreca, Susan D.,Lyssikatos, Joseph P.,Moraski, Garrett,Ng, Karl,Raggon, Jeffrey W.,Stewart, A. Morgan,Tickner, Derek L.,Tucker, John L.,Urban, Frank J.,Vazquez, Enrique,Wei, Lulin
-
p. 643 - 650
(2013/09/02)
-
- A novel thiourea ligand applied in the Pd-catalyzed Heck, Suzuki and Suzuki carbonylative reactions
-
A novel C2 symmetrical and sterically bulky thiourea ligand 1 has been successfully applied to Heck, Suzuki and Suzuki-type carbonylative coupling reactions under aerobic conditions. Since the metal-sulfur bond in the thiourea complexes is stronger than the metal-phosphorus bond of typical phosphine complexes, thiourea ligands generally do not easily dissociate from the metal center under catalytic conditions, which establishes the thiourea 1-based palladium complexes as effective catalysts for the palladium-catalyzed cross-coupling reactions.
- Mingji, Dai,Liang, Bo,Wang, Cuihua,You, Zejin,Xiang, Jing,Dong, Guangbin,Chen, Jiahua,Yang, Zhen
-
p. 1669 - 1673
(2007/10/03)
-
- Synthesis of Diaryl Ketones Catalyzed by Al2O 3-ZrO2/S2O82- Solid Superacid
-
The acylation of a variety of aromatic compounds with benzoyl chloride or its derivatives and catalytic amounts of Al2O3-ZrO 2/S2O82- solid superacid affords the corresponding diaryl ketones in good to excellent yields 75-93% at appropriate temperature.
- Jin, Tong-Shou,Yang, Mi-Na,Feng, Guo-Liang,Li, Tong-Shuang
-
p. 479 - 485
(2007/10/03)
-
- Nucleophilic acylation of arylfluorides catalyzed by imidazolidenyl carbene
-
Imidazolidenyl carbene catalyzes nucleophilic acylation reaction of arylfluorides with electron withdrawing groups to give benzophenone derivatives.
- Suzuki, Yumiko,Toyota, Tomonori,Imada, Fumie,Sato, Masayuki,Miyashita, Akira
-
p. 1314 - 1315
(2007/10/03)
-
- Studies on the Insecticidal Activities of Some New N-Benzoyl-N'-Arylureas
-
This paper reports the synthesis and the insecticidal activities of some N-benzoyl-N'-arylureas 4-arylsubstituted with alkylated or halogenated aroyl moieties. The compounds, tested against some representative insect species, displayed very high activity against Aedes aegypti, especially the halosubstituted derivatives. None of the newly synthesized compounds showed genotoxic activity in the Bacillus subtilis rec-assay and in the Salmonella-microsome test.
- Carmellino, Maria L.,Pagani, Giuseppe,Pregnolato, Massimo,Terreni, Marco,Caprioli, Vincenzo,Zani, Franca
-
p. 227 - 236
(2007/10/03)
-
- N-phenyl-2-cyano-3-hydroxy-propenamides
-
A compound selected from the group consisting of a compound of the formula STR1 wherein R1 is selected from the group consisting of alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms and alkenyl and alkynyl of 2 to 6 carbon atoms, R2 is hydrogen or alkyl of 1 to 3 carbon atoms, Y is selected from the group consisting of STR2 Z1 and Z2 are individually selected from the group consisting of hydrogen, halogen, --NO2, --CN and alkyl of 1 to 3 carbon atoms, R3 is hydrogen or alkyl of 1 to 3 carbon atoms, m is an integer from 0 to 6, R4, R5, R6, R7 and R8 are individually selected from the group consisting of hydrogen, halogen, --CN, --NO2, alkyl, alkylthio and alkoxy of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, --COR10, --(CH2)n --CX3, --O--(CH2)n CX3 and --S--(CH2)n --CX3, R10 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and cycloalkyl of 3 to 6 carbon atoms, n is an integer from 0 to 3, X is halogen or R6 and R7 together form --O--CH2 --O-- and their non-toxic, pharmaceutically acceptable salts with a base having anti-inflammatory and immunomodulatory activity.
- -
-
-
- Aromatic ether-ketone polyamines, intermediates and products, and methods for preparing same
-
Novel aromatic ether ketone diamine compounds and methods for their preparation are disclosed which comprise from about 3 to 8 aromatic rings interspersed with ether and ketone linkages. The novel ether ketone diamine compounds are useful as monomeric starting materials for the preparation of useful intermediates and useful thermoplastic and high temperature resistant polymers. In preferred embodiments, the novel ether ketone diamines are useful as curing agents for epoxy resin compositions and composite materials.
- -
-
-
- HIGH-TEMPERATURE BENZOYLATION
-
The benzoylation of aromatic hydrocarbons by benzoyl chloride and its substituted derivatives at 250-270 deg C takes place in a steel autoclave in the absence of Lewis acids.The reaction is catalyzed by the surface of the autoclave.The virtual presence of only para-substituted benzophenones in the reaction products is due to isomerization processes both in the initial substituted benzoyl chloride and in the final benzophenone.
- Mil'to, V. I.,Mironov, G. S.,Kopeikin, V. V.
-
p. 2139 - 2141
(2007/10/02)
-
- Acrylic acid heterocyclic amides, fungicidal compositions and use
-
Compounds of the formula STR1 wherein A, B, R1, X and Q are substituents of various types, and acid addition salts thereof. The compounds are useful as fungicides.
- -
-
-
- Reaction of Diazonium Salts with Transition Metals. Part 13. Palladium-catalyzed Carbonylative Coupling of Arenediazonium Salts with Organotin Reagents to give Aromatic Ketones
-
Palladium-catalyzed reactions of arenediazonium salts (ArN2X; Ar=Y-Ph, Y=H, 2-, 3-, 4-Me, 2-Ph, 2-, 3-MeO, 2-, 3-, 4-Cl, 4-Br, 4-I, 2-, 3-, and 4-NO2, X=BF4 and PF6) with carbon monoxide and organostannanes (R4Sn, R=Me, Et, and Ph; RSnMe3, R=Ph, 2-, 3-, 4-MeC6H4, and 4-ClC6H4; RSnEt3, R=4-NO2C6H4; RSnBu3, R=Ph) gave aromatic ketones (ArCOR) in good yields (40-95percent) at room temperature.
- Kikukawa, Kiyoshi,Idemoto, Tohru,Katayama, Atsuhiko,Kono, Kiyoshi,Wada, Fumio,Matsuda, Tsutomu
-
p. 1511 - 1514
(2007/10/02)
-
- Carboxylic Trifluoromethanesulfonic Anhydrides as Highly Effective Acylation Agents. - Perfluoroalkanesulfonic Acid Catalyzed Acylation of Arenes
-
Arene- and alkanecarboxylic trifluoromethanesulfonic anhydrides 2 and 5 are highly effective acylation agents, which react without Friedel-Crafts catalysts even with deactivated aromatics to yield aryl ketones 3 and 6, respectively.Acylation of arenes with carbonyl chlorides 4 and catalytic amounts of perfluoroalkanesulfonic acid gives ketones 3 and 6, resp., in good yields.Under similar conditions other strong Broensted acids show a considerably smaller degree of catalytic effect.
- Effenberger, Franz,Sohn, Erich,Epple, Gerhard
-
p. 1195 - 1208
(2007/10/02)
-
- Benzophenone ureas and method for utilizing the same
-
This invention provides for novel benzophenone ureas, a method for preparing the same, and a method for controlling undesirable broadleaf weeds and grasses therewith, wherein said benzophenone is represented by the generic formula: SPC1 Where A and B each represent hydrogen, methyl, halogen, trifluoromethyl, or methoxy; R1 and R2 are taken singly or in combination and represent hydrogen, lower alkyl, alkoxy, alkoxyalkyl, cycloalkyl, cyclohetero, loweralkylamino, lower alkenyl or lower alkynyl, with the proviso that A is either meta or para to the --HN--CO--NR1 R2 substituent.
- -
-
-