- Cis-cyclohexyl - 1, 2 - dicarboxylic imide synthetic method (by machine translation)
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The invention discloses cis-cyclohexyl - 1, 2 - dicarboxylic imide synthetic method. In order to phthalimide and hydrogen as a raw material, under the catalysis of the catalyst prepared in high yield cis-cyclohexyl - 1, 2 - dicarboxylic imide. The invention through changing the process conditions to achieve the purpose of avoid side reaction, and finally achieves the high selectivity of the reaction, high conversion rate; reaction liquid through simple distillation, crystallization can be obtained filter means of 98% content product of the above; by adding is great and copper powder load alumina composite catalyst as a catalyst to catalyze the reaction, the reaction selectivity can reach 93.05%, yield can reach 94.11%. (by machine translation)
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Paragraph 0036; 0041; 0044; 0045; 0046; 0047; 0048
(2018/09/21)
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- An expedient and convenient approach for one-pot synthesis of 1H-isoindole-1,3(2H)-diones
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An easy and expedient method for the one-pot synthesis of 1H-isoindole-1,3(2H)-diones has been developed by the reaction of the corresponding cyclic anhydrides with guanidinium chloride as a nitrogen source in the presence of FeCl3 as a catalyst under mild reaction conditions.
- Ekhtiari, Zeinab,Havasi, Forugh,Nikpour, Farzad
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p. 941 - 944
(2016/10/13)
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- Straightforward synthesis of 1,2-dicyanoalkanes from nitroalkenes and silyl cyanide mediated by tetrabutylammonium fluoride
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A straightforward synthesis of 1,2-dicyanoalkanes by reacting nitroalkenes with trimethylsilyl cyanide in the presence of tetrabutylammonium fluoride is described. The reaction proceeds through a tandem double Michael addition under mild conditions. Employing the hypervalent silicate generated from trimethylsilyl cyanide and tetrabutylammonium fluoride is essential for achieving this transformation. Mechanistic studies suggest that a small amount of water included in the reaction media plays a key role. This protocol is applicable to various types of substrates including electron-rich and electron-deficient aromatic nitroalkenes, and aliphatic nitroalkenes. Moreover, vinyl sulfones were found to be good alternatives, particularly for electron-deficient nitroalkenes. The broad substrate scope and functional group tolerance of the reaction makes this approach a practical method for the synthesis of valuable 1,2-dicyanoalkanes.
- Kiyokawa, Kensuke,Nagata, Takaya,Hayakawa, Junpei,Minakata, Satoshi
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p. 1280 - 1285
(2015/02/19)
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- Efficient catalytic hydrogenation of N-unsubstituted cyclic imides to cyclic amines
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The hydrogenation of N-unsubstituted cyclic imides to the corresponding cyclic amines has been performed selectively with heterogeneous catalysts obtained from rhodium and molybdenum carbonyl precursors. Various substrates were reduced in good to high yields and selectivities. Platinum-based catalysts also proved to be efficient. Furthermore, gram-scale experiments were performed and the catalysts could be recycled.
- Maj, Anna M.,Suisse, Isabelle,Pinault, Nathalie,Robert, Nicolas,Agbossou-Niedercorn, Francine
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p. 2621 - 2625
(2015/04/14)
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- New polymers possessing a disulfide bond in a unique environment
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The synthesis and some of the physical properties of the first poly(disulfidediamines) are reported. The disulfidediamine functional group (R2NSSNR2) possesses a disulfide bond in a unique environment that leads to a low bond dissociation energy (calculated BDE of 43.1 kcal mol-1). These polymers were synthesized in high yields and with conversions up to >98% by reactions between secondary diamines and a new disulfide monomer. The disulfide monomer was synthesized in two steps without the need for column chromatography. The polymerizations were robust and completed at room temperature, under ambient atmospheric conditions, and in solvents that were used as purchased. These polymers were stable, but they rapidly decomposed under acidic, aqueous conditions or by heating to 175 °C as shown by thermal gravimetric analysis. The first fully conjugated poly(disulfidediamine) was synthesized, and its electrical conductivity was characterized in the solid state.
- Graf, Tyler A.,Yoo, Jun,Brummett, Adam B.,Lin, Ran,Wohlgenannt, Markus,Quinn, Daniel,Bowden, Ned B.
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p. 8193 - 8200
(2013/01/15)
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- The synthesis of unsubstituted cyclic imides using hydroxylamine under microwave irradiation
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Unsubstituted cyclic imides were synthesized from a series of cyclic anhydrides, hydroxylamine hydrochloride (NH2OH·HCl), and 4-N,N-dimethylamino-pyridine (DMAP, base catalyst) under microwave irradiation in monomode and multimode microwaves. This novel microwave synthesis produced high yields of the unsubstituted cyclic imides for both the monomode (61-81%) and multimode (84-97%) microwaves.
- Benjamin, Ellis,Hijji, Yousef
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p. 157 - 169
(2008/09/17)
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- Efficient microwave assisted syntheses of unsubstituted cyclic imides
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A number of cyclic imides were synthesized from cyclic anhydrides using ammonium chloride (NH4Cl), and 4-N,N-dimethylaminopyridine (DMAP) or with ammonium acetate (NH4OAc) under microwave irradiation in both a mono-mode and a conventional microwave. Several substituted succinic anhydrides used as reactants were synthesized efficiently by Diels-Alder reactions of maleic anhydride with 1,3-cyclohexadienes in 63-82% for the mono-mode and 72-92% in the conventional microwave ovens. Cyclic imides were synthesized with yields from 50-98%.
- Hijji, Yousef M.,Benjamin, Ellis
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p. 2259 - 2267
(2007/10/03)
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- A facile and convenient synthesis of 1H-isoindole-1,3(2H)-diones
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A facile synthesis of 1H-isoindole-1,3(2H)-diones (3a-h) has been developed by the reaction of the corresponding anhydrides (1a-h) with potassium cyanate (4a) or sodium thiocyanate (4b). The reactions were carried out in neutral media under reflux or under microwave irradiation without use of catalyst. Good to excellent yields of the products were obtained in high purity with very simple work-up.{A figure is presented}.
- Nikpour, Farzad,Kazemi, Samira,Sheikh, Davood
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p. 1559 - 1564
(2007/10/03)
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- Asymmetric desymmetrization of meso-pyrrolidine derivatives by enantiotopic selective C-H hydroxylation using (salen)manganese(III) complexes
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Chiral (salen)manganese(III) complexes 1 catalyzed the asymmetric desymmetrization of N-protected meso-pyrrolidine derivatives 3, 6-8, 15 and 18 by enantiotopic selective C-H oxidation in the presence of terminal oxidant iodosylbenzene. The oxidation occurred chemoselectively at the carbon α to the nitrogen atom to afford optically active hydroxypyrrolidine derivatives 9, 11, 13, 16, 19 and 21 that were further oxidized to chiral lactams with Jones reagent. The N-protecting groups of the meso-pyrrolidine derivatives have notable effect on the enantioselectivity.
- Punniyamurthy,Katsuki, Tsutomu
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p. 9439 - 9454
(2007/10/03)
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- Benzodiazepine derivatives
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Compounds of Formula (I), and salts and prodrugs thereof, wherein R1 represents H, optionally substituted C1-6 alkyl or C3-7 cycloalkyl; R2 is NHR12 or (CH2)s R13 where 5 is 0, 1 or 2; R3 represents C1-6 alkyl, halo or NR6 R7 ; R4 and R5 are H, C1-12 alkyl optionally substituted by NR9 R9' or an azacyclic or azabicyclic group, optionally substituted C4-9 cycloalkyl, C4-9 cycloalkyl C1-4 alkyl, aryl, arylC1-6 alkyl or azacyclic or azabicyclic groups, or R4 and R5 together form the residue of an optionally substituted azacyclic or azabicyclic ring system; x is 0, 1, 2 or 3; R12 is optionally substituted phenyl or pyridyl; R13 represents a group (A) wherein R14 is H or C1-6 alkyl; R15 is H, C1-6 alkyl, halo or NR6 R7 ; and the dotted line is an optional covalent bond; are CCK and/or gastrin antagonists useful in therapy. STR1
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- Incorporation of Molecular Nitrogen Into Organic Compounds. Titanium Catalyzed Nitrogenation
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Incorporation of molecular nitrogen into organic compounds was realized using a catalytic amount of TiCl4 in the presence of excess TMSCl and Li.Various imides were prepared from the corresponding acid anhydrides by use of this catalytic system.
- Mori, Miwako,Kawaguchi, Mami,Hori, Masanori,Hamaoka, Shin-ichi
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p. 729 - 740
(2007/10/02)
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- Metal Carbonyl Complexes with Anions of Cyclic Imides
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A large series of metal carbonyl complexes with N-bonded anions of various cyclic imidates (X(-)) has been prepared: (-), (-), (-) (M = Cr, Mo, W), Re(CO)5X, (-), (-).Also pyromellitdiimidate and cyclopentanebis(dicarboximidate) bridged complexes (2-) (M = Cr, Mo, W) and the dicyanamide complex (-) have been obtained.Reactions at the coordinated imidate ligands and the spectroscopic data of the complexes are reported. - Keywords: Chromium, Molybdenum, Tungsten, Manganese Carbonyls, Anions of Cyclic Imides as Ligands
- Schier, Ernst-Juergen,Sacher, Wolfgang,Beck, Wolfgang
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p. 1424 - 1434
(2007/10/02)
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