- Highly Efficient DMSO-Promoted α-Hydrolysis of α-Halohydroxamates under Mild Conditions
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A novel and efficient method for the nucleophilic α-hydrolysis of α-halohydroxamates with water under metal-free conditions is described. In this reaction, the simple and readily available dimethyl sulfoxide (DMSO) was used as a catalyst, while water serv
- Yoon Lee, Chang,Kim, Sung-Gon
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p. 1607 - 1614
(2021/02/26)
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- O-Protected 3-hydroxy-oxazolidin-2,4-diones: Novel precursors in the synthesis of α-hydroxyhydroxamic acids
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O-Protected 3-hydroxyoxazolidin-2,4-diones have been prepared in a novel one-pot reaction by subsequent treatment of cyanohydrins with 1,1′-carbonyldiimidazole and O-protected hydroxylamines followed by acidic hydrolysis of the intermediate 4-imino-oxazolidin-2-ones. Decarbonylation of O-protected 3-hydroxyoxazolidin-2,4-diones by catalytic amounts of sodium methoxide, lithium hydroxide, sodium carbonate and caesium carbonate in methanol afforded O-protected α-hydroxyhydroxamic acids in excellent yields. Their deprotection provided a series of novel α-hydroxyhydroxamic acids.
- Kurz, Thomas,Widyan, Khalid
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p. 2023 - 2027
(2007/10/03)
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