- Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora
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Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC50 values of 0.014 and 0.23 μM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC50 values of 4.04 and 2.32 μM, respectively.
- Yenjai, Chavi,Wanich, Suchana
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supporting information; experimental part
p. 2821 - 2823
(2010/08/06)
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- Efficient one-pot synthesis of hydroxyflavanones by cyclization and O-demethylation of methoxychalcones
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An efficient one-pot method for the synthesis of hydroxyflavanones is described. Methoxychalcones are treated with 36% HBr to afford cyclization and regioselective O-demethylation products (2a-i) while cyclization and complete O-demethylation products (3a
- Liu, Tao,Ying, Huazhou,Lin, Guan,Hu, Yongzhou
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p. 1815 - 1821
(2008/12/20)
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- Variations in the chemical shift of the 5-hydroxyl proton of 7-o-prenylated flavanones
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In 1H nmr examination of 6- or 8-prenylated flavanone 7-methyl and 7-prenyl ethers, the signals of hydrogen-bonded hydroxyl proton appeared in relatively narrow region. Relatively large solvent effect was observed on the signal of 6-prenylflavanone 7-methyl and 7-prenyl ethers.
- Fukai, Toshio,Nomura, Taro
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p. 1361 - 1364
(2007/10/03)
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- THE OCCURRENCE OF FLAVANONES IN THE FARINOSE EXUDATE OF THE FERN ONYCHIUM SILICULOSUM
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The yellow farina on fertile pinnules of Onychium siliculosum is composed of 2',6'-dihydroxy-4'-methoxychalcone and 2',6'-dihydroxy-4,5'-dimethoxychalcone.Heating of the crude extract brings about isomerization to pinostrobin and to 5-hydroxy-7,8-dimethoxyflavanone and 5-hydroxy-6,7-dimethoxyflavanone, respectively.The latter flavanone, recently reported as a constituent of this fern, is thus not a natural product. - Key Word Index: Onychium siliculosum; Pteridophyta; frond exudate; chalcone isomerization; 5-hydroxy-7,8-dimethoxyflavanone; 5-hydroxy-6,7-dimethoxyflavanone.
- Wollenweber, Eckhard
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p. 1462 - 1464
(2007/10/02)
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