SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
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Page/Page column 203
(2008/12/05)
SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened orhedgehog activity.
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Page/Page column 203
(2008/12/05)
PROCESSES FOR THE PREPARATION OF COMPOUNDS
The present invention provides improved synthetic methods for the preparation of compounds that modulate proliferation or differentiation in a cell or tissue.
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Page/Page column 115-116
(2010/11/28)
THERAPEUTIC AGENTS, AND METHODS OF MAKING AND USING THE SAME
In part, the present invention is directed to antibacterial compounds
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Page/Page column 107
(2010/11/27)
The Synthesis of Difluorobenzothienoquinolines and Their N-Methyl Quaternary Salts
A series of difluorobenzothienoquinolines has been prepared by photocyclization of the appropriate carboxamides.The lactams obtained were converted into the corresponding chloro derivatives which were catalytically dechlorinated into the difluorobenzothienoquinolines.The latter compounds were transformed into the N-methyl quaternary salts.
Luo, Jiann-Kuan,Castle, Steven L.,Castle, Raymond N.
p. 2047 - 2052
(2007/10/02)
Sythesis of substituted Benzothiophenes
Cyclization of the cinnamic acids 1a-t and their derivatives 1u,1v, and 1w with thionyl chloride affords the benzothiophenes 2a-t and 2v,w, respectively. 2a and 2v,w have been also prepared in an independent way from the corresponding alkynes and disulfur dichloride.
Ried, Walter,Oremek, Gerhard,Ocakcioglu, Belkis
p. 1424 - 1427
(2007/10/02)
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