- 3 - Ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture of synthetic method
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The invention belongs to the field of medicinal chemistry, in particular to medicinal chemistry of the in the field of organic synthesis, more in particular to 3 - ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture of synthetic method. The method uses acetonitrile with a ester alcohol under the action of the alkali metal salt, to obtain the intermediate compound II, then this compound II and then under the action of the phase transfer catalyst, with the sulfuric acid b b obtained by the target mixture compound I, namely 3 - ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture. The invention disclosed 3 - ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture of the synthetic method has low material cost, relatively mild reaction conditions, the operation is simple, the yield and the like, which is suitable for the industrial production, application of the method.
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Paragraph 0037; 0038; 0039; 0040-0048
(2019/07/05)
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- Method for synthesizing cytosine
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The invention discloses a method for synthesizing cytosine. The method comprises the following steps: taking charcoal and carbon dioxide as raw materials, and obtaining mixed gas through one-pot reaction; directly reacting with acetonitrile under the action of alkali without separation; finally condensing and cyclizing with urea to obtain the cytosine. The method disclosed by the invention has the benefits that the raw materials are cheap and easy to obtain, the use of an expensive, toxic and harmless reagent is avoided, the use of dangerous and corrosive operation steps is avoided, and the environmental protection and the industrial production are facilitated. The method disclosed by the invention provides a new synthetic pathway for the cytosine and has a potential application prospect.
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Paragraph 0017; 0018; 0020; 0021; 0023; 0024; 0026-0029
(2017/07/20)
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- Synthesis and reactivity of pyrrolo[3,2-d][1,3]oxazine-2,4-dione. Access to new pyrrolo[3,2-e][1,4]diazepine-2,5-diones
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A convenient synthesis of pyrrolo[3,2-d][1,3]oxazine-2,4-dione 4 is described and its reactivity towards various nucleophiles studied. The regioselective ring opening of anhydride 4 or its N-alkylated analog 25 in the presence of alanine or proline afforded, respectively, imidazolidinedione 22 and N-protected pyrrolo[3,2-e][1,4]diazepines 30 and 31 in a one-pot process. In a last part of this study, an alternative route to produce a library of eight non protected pyrrolo[3,2-e][1,4]diazepine-2,5-diones 35a-h is described to overcome the limited reactivity of anhydride 4.
- Malcor, Jean-Daniel,Brouillette, Yann,Graffion, Julien,Spielmann, Kim,Masurier, Nicolas,Maillard, Ludovic T.,Martinez, Jean,Lisowski, Vincent
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p. 4631 - 4639
(2014/06/23)
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