- Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors
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FabH, β-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and Gram-negative bacteria. A series of o-hydroxybe
- Li, Zi-Lin,Li, Qing-Shan,Zhang, Hong-Jia,Hu, Yang,Zhu, Di-Di,Zhu, Hai-Liang
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experimental part
p. 4413 - 4420
(2011/09/19)
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- Synthesis of new benzoxazaphosphinine/benzoxazaphosphole/ diazaphosphaphenalene-2-sulfides using Lawesson's reagent
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Synthesis of new benzoxazaphosphinine/benzoxazaphosphole/ diazaphosphaphenalene 2-sulfides were accomplished by the reaction of Lawesson's reagent (LR) with 4-bromo-2-[(phenylamino) methyl]phenol (1a), 4-bromo-2-[(4-chloro/bromo/methoxy/methylphenyl-amino)methyl]phenol (1b-e), 4-bromo-2-[(benzylamino)methyl]phenol (1f), 2-amino-4-chlorophenol (2a)/2-amino-4-methylphenol (2b), 1,8-diaminonaphthalene (3) respectively in anhydrous toluene. Products 4a-f, 5a-b and 6 were characterized by IR, 1H, 13C, 31P NMR and Mass spectra. Copyright Taylor & Francis Group, LLC.
- Prasad, G. Syam,Babu, B. Hari,Reddy, C. Devendranath,Raju, C. Naga,Reddy, C. Suresh
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- Synthesis of substituted salicylamines and dihydro-2H-1,3-benzoxazines
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Phenols were converted to their magnesium salts with the MgCl2-Et3N base system and subsequently reacted with Eschenmoser's salt, affording N,N-dimethyl substituted benzylamines in high to excellent yields. A series of mono N-substituted benzylamines were prepared in one-pot syntheses by ortho-formylation of phenols to corresponding salicylaldehydes, which in turn reacted with amines to imines. The imines were subsequently reduced to mono N-substituted benzylamines. Some of these benzylamines were further converted, without work-up, to mono N-substituted dihydro-2H-1,3-benzoxazines.
- Anwar, Hany F.,Skatteb?l, Lars,Hansen, Trond Vidar
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p. 9997 - 10002
(2008/02/13)
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