Synthesis of [14C] acids from their unlabeled counterparts and application toward a novel [14C] labeled hepatitis C virus polymerase inhibitor
A strategy has been developed for the rapid construction of a [ 14C] acid from either an aromatic or an alkyl acid via a decarboxylation-carboxylation sequence. A [14C] labeled heptatitis C virus polymerase inhibitor was prepared. Other examples and the limitations of this methodology are discussed. Copyright
Ho, Jonathan Z.,Wallace, Michael A.,Tang, Yui S.,Zhang, Andy S.,Braun, Matthew P.