Pd-catalyzed chemoselective cross-coupling reaction of triaryl- or triheteroarylbismuth compounds with 3,6-dihalopyridazines
The cross-coupling reactions of 3,6-dihalopyridazines with triaryl- or triheteroarylbismuth compounds were performed under palladium catalysis. The reaction was highly chemoselective, affording functionalized aryl- or heteroarylpyridazinyl chlorides in moderate to good yields. The cross-coupling reactions of 3,6-dihalopyridazines with triaryl- or triheteroarylbismuth compounds were performed under palladium catalysis. The reaction was highly chemoselective, affording functionalized aryl- or heteroarylpyridazinyl chlorides in moderate to good yields. Copyright
Synthesis and Anxiolytic Activity of 6-(Substituted-phenyl)-1,2,4-triazolopyridazines
The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolopyridazines (VIII) is reported.Some of these derivatives show activity in tests predictive of anxiolytic activity (a) protection against pentylenetetrazole-induced convulsions; (b)
Albright, J. D.,Moran, D. B.,Wright, W. B.,Collins, J. B.,Beer, B.,et al.
p. 592 - 600
(2007/10/02)
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