Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
-
Page/Page column 25
(2012/11/08)
PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES
The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of var
-
Page/Page column 225-226
(2008/06/13)
A convenient protocol for the synthesis of hindered aryl malononitriles
A technically feasible method has been developed for the synthesis of variety of aryl malononitriles in high yields (70-95%) using the palladium-catalyzed coupling reaction of malononitrile with aryl bromides and chlorides, respectively. The influence a s
Synthesis of 2,6-disubstituted pyridines by lithiation of pyrazolo[1,5-a] pyridines
Lithiation of 3-(4,4-dimethyl-2-oxazolin-2-yl)pyrazolo[1,5-a]pyridine (1a); with 2 molar equivalents of n-BuLi followed by reaction with benzaldehyde) yielded α-(4,4-dimethyl-2-oxazolidinylidene)-6-(α-hydroxybenzyl)- 2-pyridineacetonitrile (2a). Upon simi
Miyashita,Sato,Watanabe,Tanji,Higashino
p. 174 - 176
(2007/10/02)
More Articles about upstream products of 77035-44-0