- Hepatitis C Virus Inhibitors
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Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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Page/Page column 134
(2008/12/05)
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- Inhibitors of Hepatitis C Virus
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Macrocyclic peptides are disclosed having the general formula: wherein R3, R3′, R4, R6, R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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Page/Page column 61
(2008/12/04)
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- Inhibitors of Hepatitis C Virus
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Macrocyclic peptides are disclosed having the general formula: wherein R3, R′3, R4, R6, R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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Page/Page column 60
(2008/12/04)
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- Inhibitors of Hepatitis C Virus
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Macrocyclic peptides are disclosed having the general formula: wherein R3, R3′, R4, R6, R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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Page/Page column 57
(2008/12/04)
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- Hepatitis C virus inhibitors
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Macrocyclic peptides are disclosed having the general formula: wherein R′, R3, R3′, R4, R6, X, Q, and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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Page/Page column 61-62
(2010/11/26)
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- Novel nucleotide triphosphates as potent P2Y2 agonists
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The synthesis and P2Y2 activities of a novel series of nucleoside triphosphates are described. Many of these compounds were potent agonists of the P2Y2 receptor.
- Brookings, Daniel,Davenport, Richard J.,Davis, Jeremy,Galvin, Frances C.A.,Lloyd, Steve,Mack, Stephen R.,Owens, Ray,Sabin, Verity,Wynn, Joanne
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p. 562 - 565
(2007/10/03)
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- Simple synthesis of 4-substituted 1(2H)-isoquinolinones via electrophilic trapping of lithiated mono- and dianion precursors
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Synthetic routes have been developed to access 4-substituted 1(2H)-isoquinolinones from readily available precursors. This is achieved via electrophilic trapping of di- and monolithium anions derived from alkyllithium exchange of 4-bromo-1(2H)-isoquinolinones and corresponding 4-bromo-1- methoxyisoquinolines, respectively. Products derived from the latter are then hydrolyzed to the target 4-substituted 1(2H)-isoquinolinones. The methodology has potential application to access 4-substituted 1(2H)-isoquinolinones with additional substituents in either ring. Copyright Taylor & Francis Group, LLC.
- Sercel, Anthony D.,Sanchez, Joseph P.,Showalter, H. D. Hollis
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p. 4199 - 4208
(2008/03/13)
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- Hepatitis C virus inhibitors
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The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which inhibit the function of the NS3 protease (also referred to herein as “serine protease”) encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS3 protease.
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Page/Page column 73-74
(2008/06/13)
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- Pyridine derivatives inhibiting angiogenesis and/or vegf receptor tyrosine kinase
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The invention relates to pyridine derivatives of formula (I), wherein the substituents and symbols are defined as indicated in the description, processes for the preparation thereof, their usage in the preparation of a pharmaceutical composition for the treatment of a disease which responds to an inhibition of angiogenesis, and pharmaceutical compositions containing such compounds.
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- HEPATITIS C VIRUS INHIBITORS
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Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.
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Page 323-324
(2008/06/13)
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- SYNTHESIS OF NITROGEN HETEROCYCLES VIA PALLADIUM-CATALYZED INTRAMOLECULAR CYCLIZATION
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Catalytic amounts of Pd(OAc)2 in the presence of n-Bu4NCl, DMF and an appropriate base (Na2CO3, NaOAc or Et3N) cyclize nitrogen-containing o-iodoaryl alkenes to indoles, indolines, oxindoles, quinolines, isoquinolines and isoquinolones in short reaction times, under mild temperatures, and in high yields.
- Larock, Richard C.,Babu, Srinivasan
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p. 5291 - 5294
(2007/10/02)
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- Base-Catalysed Nitrosation of 1-Indanones - A Novel Ring Expansion Reaction
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The 1-indanones 1-4, substituted in the five-membered ring, react with butyl nitrite in the presence of sodium methoxide to give exclusively the 2-hydroxyisocarbostyrils 8-11.In the absence of substituents (5-7) the reaction is accompanied by the formation of 2-hydroxyimino derivatives (22-24) which are obtained as main products.
- Chatterjea, Jnanendra Nath,Bhakta, Chittaranjan,Sinha, Anil Kumar,Jha, Hem Chandra,Zilliken, Fritz
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