- N-[(substituted five-membered di- or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia
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NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.
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- AMIDE COMPOUNDS AND MEDICINAL USE THEREOF
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The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.
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- CONVERSION DE L'ACETYL-5 URACILE EN DERIVES PYRAZOLIQUES PAR L'HYDRAZINE ET LES HYDRAZINES MONOSUBSTITUEES
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5-Acetyl uracile 1 is easily transformed by hydrazine and methylhydrazine into 4-allophanoyl-3-methyl pyrazole 2 (R=H) and 4-allophanoyl-1,3-dimethyl pyrazole 2 (R=CH3).The pyrazoles 2, in boiling butanol and in the presence of hydrochloric acid lead resp
- Bajnati, Abdelilah,Hubert-Habart, Michel
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p. 540 - 547
(2007/10/02)
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