- New oncostatic nitrosourea of clinical interest. I. Synthesis and identification of CNCC
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This paper describes CNCC synthesis, a mixture of the three nitrosourea isomer corresponding to cystamine as the starting compound. The regioselective synthesis of one of these isomeric products is described and the structure of this compound is determined by the usual analytical approaches: NMR, HPLC.
- Oiry,Imbach
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p. 305 - 309
(2007/10/02)
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- New oncostatic nitrosourea of clinical interest. II. Study of CNCC constituents
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CNCC is an isomeric mixture of dinitrosated chloroethyl nitrosoureas. Two of these being identified, a complete analysis of the isolated mixture obtained through nitrosation of the urea corresponding to cystamine is then possible. Furthermore, a new synth
- Oiry,Pompon,Madelmont,Imbach
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p. 311 - 314
(2007/10/02)
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- Activated N-Nitrosocarbamates for Regioselective Synthesis of N-Nitrosoureas
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A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N-nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed.N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N-nitrosoureas.As an interesting example, N,N'-biscystamine, a new attractive oncostatic derivative, has been prepared.The cytotoxic activity of these various compounds were tested on L1210 leukemia.
- Martinez, Jean,Oiry, Joel,Imbach, Jean Louis,Winternitz, Francois
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p. 178 - 182
(2007/10/02)
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