N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase
A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.
Yin, Zheng,Chen, Yen-Liang,Kondreddi, Ravinder Reddy,Chan, Wai Ling,Wang, Gang,Ng, Ru Hui,Lim, Joanne Y. H.,Lee, Wan Yen,Jeyaraj, Duraiswamy A.,Niyomrattanakit, Pornwaratt,Wen, Daying,Chao, Alex,Glickman, J. Fraser,Voshol, Hans,Mueller, Dieter,Spanka, Carsten,Dressler, Sigmar,Nilar, Shahul,Vasudevan, Subhash G.,Shi, Pei-Yong,Keller, Thomas H.
supporting information; scheme or table
p. 7934 - 7937
(2010/07/07)
Synthesis of pinacol esters of 1-alkyl-1H-pyrazol-5-yl- and 1-alkyl-1H-pyrazol-4-ylboronic acids
Starting from 1H-pyrazol, a wide number of 1-alkyl-1H-pyrazol-4-yl and 1-alkyl-1H-pyrazol-5-ylboronic acids and their pinacol esters were synthesized and characterized. The key step in the described methodology is the regioselective lithiation of the pyrazole ring. The synthesized pinacolates are stable under prolonged storage and can be used as convenient reagents in organic synthesis.
Ivachtchenko, Alexandre V.,Kravchenko, Dmitry V.,Zheludeva, Valentina I.,Pershin, Dmitry G.
p. 931 - 939
(2007/10/03)
More Articles about upstream products of 777063-41-9