cas 78-96-6, Amino-2-propanol | Articles data

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ZEOLITE CATALYZED PROCESS FOR THE AMINATION OF PROPYLENE OXIDE
The present invention relates to a process for the conversion of propylene oxide to 1-amino-2- propanol and/or di(2-hydroxypropyl)amine comprising (i) providing a catalyst comprising a zeolitic material comprising YO2 and optionally comprising X2O3 in its framework structure, wherein Y is a tetravalent element and X is a trivalent element, wherein the zeolitic material has a framework-type structure selected from the group consisting of MFI and/or MEL, including MEL/MFI intergrowths; (ii) providing a mixture in the liquid phase comprising propylene oxide and ammonia; (iii) contacting the catalyst provided in (i) with the mixture in the liquid phase provided in (ii) for converting propylene oxide to 1-amino-2-propanol and/or di(2-hydroxypropyl)amine.
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Page/Page column 20-21

(2021/05/29)

Method for preparing monoisopropanolamine
The invention discloses a method for preparing monoisopropanolamine. The method comprises the steps of (a) reacting 1,2-propylene glycol under the action of a dehydrogenation catalyst to obtain 2-hydroxy propionaldehyde; and (b) reacting the 2-hydroxy propionaldehyde obtained in the step (1) with liquid ammonia and hydrogen under the action of a hydrogenation catalyst to prepare monoisopropanolamine. The dehydrogenation catalyst is prepared from a modified gamma-Al2O3 carrier and active components of CuO, PdO, Bi2O3 and In2O3. The hydrogenation catalyst comprises a modified gamma-Al2O3 carrierand active components NiO, V2O5 and Y2O3. Different catalysts and two-step reaction processes are adopted, and the reaction processes of dehydrogenation, imidization and hydrogenation of 1,2-propanediol are controlled to inhibit the generation of by-products such as hydroxyacetone in the dehydrogenation process and by-products such as secondary amine in the amination process, thereby greatly enhancing the yield and selectivity of the monoisopropyl alcohol product.
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Paragraph 0065; 0074; 0076-0077; 0084; 0088-0089

(2021/01/04)

Selective amination of 1,2-propanediol over Co/La3O4 catalyst prepared by liquid-phase reduction
The catalytic coupling of alcohol and ammonia is an environmentally friendly process. Cobalt-based catalysts, modified by supports (including CeO2, Fe3O4, Nb2O5, La3O4 and Al2O3), and prepared by the liquid-phase reduction, were used for the amination of 1,2-propanediol. The screened nano-Co/La3O4 catalyst exhibited an excellent catalytic performance of 68% conversion and 89% selectivity toward 2-amino-1-propanol under optimal conditions. The characterizations of the catalyst was performed by XRD, XPS, BET, TEM, TG, and CO2-TPD, revealing a relatively large specific surface area, strongly alkaline sites and a Co-La-O transition phase, which were responsible for the selective catalysis of 1,2-propanediol. The efficient construction of cobalt-based catalysts on the basis of the active species is key to improving the efficiency of the reaction process.
Yue, Chuan-Jun,Di, Kai,Gu, Li-Ping,Zhang, Zhen-Wei,Ding, Lin-Lin
(2019/08/20)

Improving the efficiency of Fenton reactions and their application in the degradation of benzimidazole in wastewater
Reducing the quantity of sludge produced in Fenton reactions can be partly achieved by improving their efficiency. This paper firstly studies the effect of uniform deceleration feeding (ferrous iron and hydrogen peroxide) on the efficiency of a Fenton reaction by measuring the yield of hydroxyl radicals (OH) and chemical oxygen demand (COD) removal rate. The dynamic behavior of OH was also investigated. The results indicated that uniform deceleration feeding was the best feeding method compared with one-time feeding and uniform feeding methods when the same amount of Fenton reagents and the same reaction times were used. Besides, it was found the COD removal rate reached 79.3% when this method was applied to degrade 2-(a-hydroxyethyl)benzimidazole (HEBZ); this COD removal rate is larger than those when the other two modes were used (they reached 60.7% and 72.1%, respectively). The degradation pathway of HEBZ was determined using PL, UV-vis, FTIR, HPLC and GC-MS. Ultimately, HEBZ was decomposed into three small molecules (2-hydroxypropylamine, oxalic acid, and 2-hydroxypropamide). This research is of great significance for the application of Fenton reactions in wastewater treatment.
Liu, Qinyao,Qian, Kun,Qi, Jinxu,Li, Chenru,Yao, Chen,Song, Wei,Wang, Yihong
p. 9741 - 9748
(2018/03/23)

Lewis acid mediated intramolecular C-O bond formation of alkanol-epoxide leading to substituted morpholine and 1,4-oxazepane derivatives: Total synthesis of (±)-Viloxazine
Substituted morpholines have been efficiently synthesised in good yields from nitrogen tethered alkanol-epoxide mediated by boron trifluoride etherate. The methodology has been used for the total synthesis of (±)-viloxazine.
Ghosh, Priya,Deka, Manash J.,Saikia, Anil K.
p. 690 - 698
(2016/01/15)

Converting urea into high value-added 2-oxazolidinones under solvent-free conditions
Zn-modified mesoporous Mg-Al nanoplates oxides were prepared by co-precipitation and further characterized and used in the synthesis of 2-oxazolidinones from urea and epoxides under solvent-free conditions. The characterization results suggested that Zn1.1Mg2.0AlO4.6, which featured more accessible active medium basic sites, were favorable for obtaining superior catalytic activity. This synthetic process is mild, convenient, simple and gives good yields up to 80%.
Wang, Peixue,Li, Qinghe,Liu, Shimin,Deng, Youquan
p. 94382 - 94386
(2016/10/21)

HIV INTEGRASE INHIBITORS
The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
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(2015/09/22)

Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors
This article reports the design, synthesis and antiviral evaluation of a new series of non-nucleoside reverse transcriptase inhibitors (NNRTIs). The basic skeleton of these target 18 molecules is diarylpyrimidine featuring a substituted amino group between the pyrimidine scaffold and the aryl wing. All of the new compounds have been characterized by spectra analysis. The entire target molecules were evaluated for their in vitro anti-HIV activity with controlling group of FDA approved drugs. Most of them showed good to potent activities against wild-type (WT) HIV-1 with IC50 values in the range of 0.0175-69.21 μM. 2-(4-Cyanophenylamino)-4-(2- cyanovinylphenylhydrazonomethyl)pyrimidine (1d) displayed potent anti-HIV-1 activity against WT HIV-1 with a selectivity index (SI) of 106367 and an IC 50 value of 1.75 nM, which was 47 fold lower than that of AZT. Compound 1d also showed a broad-spectrum inhibitory activity, with an IC 50 value of 5.33 μM and 5.05 μM against both HIV-1 double-mutated (K103N/Y181C) strain and HIV-2 strain, respectively. The preliminary structure-activity relationship (SAR) was also investigated. The binding modes with HIV-1 RT for both the wild type and mutant type have also been discussed.
Meng, Ge,Liu, Yang,Zheng, Aqun,Chen, Fener,Chen, Wenxue,De Clercq, Erik,Pannecouque, Christophe,Balzarini, Jan
p. 600 - 611
(2014/07/08)

Structure of catalytically active Rh-In bimetallic phase for amination of alcohols
The structure of Rh-In bimetallic catalysts supported on carbon for amination of alcohols was determined by XRD, TEM-EDX, XPS, CO adsorption and EXAFS. At low In/Rh ratio (In/Rh ≤ 0.2), Rh metal particles with sizes of a tetragonal RhIn alloy with a particle size of ～20 nm was formed. This tetragonal alloy has a structure with a = 0.315 nm and c = 0.328 nm where metal atoms are located at (0, 0, 0) and (0.5, 0.5, 0.5). The catalytic activity of the tetragonal RhIn alloy is much higher than that of Rh metal particles with or without indium oxide species. With an excess amount of In (In/Rh > 1) on the high Rh loading (20 wt%) catalyst, the cubic RhIn phase with a CsCl structure was observed instead of the tetragonal RhIn phase, and the catalytic activity was much decreased.
Takanashi, Tsukasa,Tamura, Masazumi,Nakagawa, Yoshinao,Tomishige, Keiichi
p. 28664 - 28672
(2014/07/22)

Amination of alcohols with ammonia in water over Rhin catalyst
Amination of various C3 alcohols such as 1,2-propanediol with ammonia was catalyzed by RhIn/C in water while Rh/C was totally inactive. Activated carbon FAC-10 was the best support in terms of activity and resistance to metal leaching. In the amination of 1,2-propanediol, RhIn/C produced amino alcohols in 68% total selectivity and 38% conversion. XRD and TEM measurements showed that RhIn alloy particle with size of 34 nm was formed on the carbon support.
Takanashi, Tsukasa,Nakagawa, Yoshinao,Tomishige, Keiichi
p. 822 - 824
(2014/06/23)

Efficient preparation of biologically important 1,2-amino alcohols
An efficient three-step methodology developed for the preparation of 1,2-amino alcohols. In the first step a rapid coupling between bromoketones and potassium phthalimide in ionic liquid produced-phthalimido ketones in quantitative yields, which is followed by a facile reduction using NaCNBH 3 in acetic acid to give corresponding phthalimido alcohols and finally effecting hydrazinolysis in water at 60C to yield biologically important 1,2-amino alcohols.
Gupta, Pankaj,Rouf, Abdul,Shah, Bhahwal A.,Mukherjee, Debaraj,Taneja, Subhash C.
p. 505 - 519
(2013/01/15)

C-H bond amination by photochemically generated transient borylnitrenes at room temperature: A combined experimental and theoretical investigation of the insertion mechanism and influence of substituents
A number of azidoboranes having substitution patterns that are derived from catechol (3), pinacol (4a), 1,2-diaminoethane (4b,c), 1,2-ethanedithiol (4d), and 1,2,4,5-tetrahydroxybenzene as well as acyclic dialkoxy species (5) were synthesized and, in the case of 4c (N,N′-ditosyl-2-azido-1,3,2- diazaborolane), also structurally characterized. The azidoboranes were photolyzed in cyclohexane solvent in order to investigate the tendency of the generated borylnitrenes to undergo intermolecular C-H insertion reactions. The yields of intermolecular insertion products ranged from very good (4a) to vanishingly small, depending on the substitution of the azidoborane. For a number of borylnitrenes the zero-field splitting parameter D was measured in organic glasses at 4 K. The small primary kinetic isotope effect (k H/kD = 1.35) measured for 4a in mixtures of [H 12]cyclohexane and [D12]cyclohexane suggests that the insertion reaction is concerted and involves the singlet state of the borylnitrene. Computations at the CBS-QB3 and CCSD(T)/TZ2P levels of theory show that the relative energies of singlet and triplet states of a wide variety of borylnitrenes and even their nature as minima or saddle points depend strongly on the substituents. Photolysis of the most reactive azidoborane, 4a, in methane in a flow reactor at atmospheric pressure produces an intermolecular insertion product in low yields, in agreement with the expectation of intersystem crossing to the less reactive triplet state of the borylnitrene.
Filthaus, Matthias,Schwertmann, Larissa,Neuhaus, Patrik,Seidel, Ruediger W.,Oppel, Iris M.,Bettinger, Holger F.
scheme or table
p. 3894 - 3903
(2012/07/13)

METHOD FOR PRODUCING AMINES FROM GLYCERIN
The present invention relates to a process for preparing amines by reacting glycerol with hydrogen and an aminating agent from the group of ammonia and primary and secondary amines in the presence of a catalyst at a temperature of from 100° C. to 400° C. and a pressure of from 0.01 to 40 MPa (from 0.1 to 400 bar). Preference is given to using glycerol based on renewable raw materials. The catalyst preferably comprises one metal or a plurality of metals or one or more oxygen compounds of the metals of groups 8 and/or 9 and/or 10 and/or 11 of the Periodic Table of the Elements. The invention further relates to the use of the reaction products as an additive in cement or concrete production and in other fields of use. This invention further provides the compounds 1,2,3-triaminopropane, 2-aminomethyl-6-methylpiperazine, 2,5-bis(aminomethyl)piperazine and 2,6-bis(aminomethyl)piperazine.
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Page/Page column 12

(2010/10/03)

Cyclization of vinyl ethers derived from amino alcohols
Cyclization of vinyl ethers derived from linear and cyclic α- and β-amino alcohols, catalyzed by mercury(II) acetate gave 2-methyloxazolidines and 2-methylperhydro-1,3-oxazines in 37-94% yield.
Kukharev,Stankevich,Klimenko,Kukhareva
p. 966 - 969
(2008/03/13)

Pyrithione biocides enhanced by zinc metal ions and organic amines
The present invention is directed to a stable, soluble, antimicrobial composition concentrate comprising pyrithione or a pyrithione complex in an amount of from about 0.5% to about 30 weight percent, a zinc source in an amount of from about 0.1% to about 10%, and an organic amine component in an amount of from about 30% to about 80%, said percents being based upon the total weight of the composition concentrate. The invention is also directed to methods of controlling the growth of free-living microorganisms or biofilms using the antimicrobial composition of the invention, and products made using the antimicrobial composition of the invention.
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(2008/06/13)

A General Route to the Synthesis of N-Protected 1-Substituted and 1,2-Disubstituted Taurines
N-Benzyloxycarbonyl protected α-substituted and αβ- disubstituted taurines were synthesized from olefins and epoxides via N-benzyloxycarbonylamino alcohol thioacetates as key intermediates. They are important sulfur analogues of naturally occurring amino acids and building blocks for the synthesis of α-substituted and α,β- disubstituted β-sulfonopeptides.
Xu, Jiaxi,Xu, Shu
p. 276 - 282
(2007/10/03)

2-(1,3,5-Dithiazinan-5-yl)ethanol heterocycles, structure and reactivity
Treatment of 2-(1,3,5-dithiazinan-5-yl)ethanol (1), 2-(1,3,5-dithiazinan-5- yl)-1-phenylethanol (2), 2-(1,3,5-dithiazinan-5-yl)-1-methylethanol (3) and 2-(1,3,5-dithiazinan-5-yl)-2-methyl-1-phenylethanol (4) with TsCl and NEt 3 in CH2Cl2 afforded the corresponding 3-tosyl-1,3-oxazolidine derivatives (5-8), whereas tosylation of 1-4 in the presence of NHMe3Cl gave the corresponding O-tosyl-2-(1,3,5- dithiazinan-5-yl)ethanol derivatives (11-14). The direct preparation of 5 and 7 from formaldehyde and N-tosylethanolamine (9) or N-tosyl-2-propanolamine was not successful. Reactions of 1 or 3 with benzylamine furnish 1,3,5-tribenzyl-1,3,5- triazinane. Heating of 1 and 2 affords the corresponding 1,3,5-tri(2- hydroxyethyl)-1,3,5-triazinanes. X-Ray diffraction studies of compounds (1-9 and 11) are reported.
Gálvez-Ruiz, Juan Carlos,Jaen-Gaspar, Javier C.,Castellanos-Arzola, Indira G.,Contreras, Rosalinda,Flores-Parra, Angelina
p. 2269 - 2285
(2007/10/03)

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS
The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed
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(2008/06/13)

Convenient methods for the hydrolysis of oxazolidinones to vicinal aminoalcohols
We have developed two convenient methods for hydrolysis of 2-oxazolidinones to the corresponding vicinal aminoalcohols. N-Substituted oxazolidinones can be readily hydrolyzed using Dowex 1×8-100 resin. N-Unsubstituted oxazolidinones cannot be hydrolyzed using Dowex resins but are effectively hydrolyzed using polymer supported ethylenediamine.
Katz, Steven J,Bergmeier, Stephen C
p. 557 - 559
(2007/10/03)

Process for delaying the formation and/or reducing the agglomeration tendency of hydrates
The invention concerns a process for delaying the formation and/or reducing the agglomeration tendency of hydrates in conditions under which a hydrate may be formed, these hydrates being formed from water and gas. The process according to the invention wherein, in particular, an additive comprising at least one compound from the group of hydroxycarbylamides of substituted carboxylic acids is used. Application of the process according to the invention to processes using gases and water, which form hydrates between them, in particular in the petroleum or gas industry.
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(2008/06/13)

Detergent and cleaning compositions containing chelating agents
The present invention relates to novel chelating agents derived from iminodiacetic acid, having the formula wherein R is selected from the group of, - (CH2)2OCH2CH3; -(CH2)3OCH2CH3;, - CH(CH3)CH2OH; -(CH2)3O(CH2)2CH3;, and M is either hydrogen or a salt-forming cation. Detergent and cleaning compositions, in particular hard-surface cleaning compositions, containing said chelating agents are also encompassed.
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(2008/06/13)

Fiber-reactive disazo brown dye having vinylsulfone-type reactive group
A compound, or a salt thereof, represented by the following formula, STR1 wherein A is a substituted or unsubstituted phenylene or naphthylene group, B is STR2 in which R3 is a hydrogen atom or a lower alkyl, lower alkoxy, acylamino or ureido group, and R4 is a hydrogen atom or a lower alkyl or lower alkoxy group, R1 and R3 are independently a hydrogen atom or a substituted or unsubstituted lower alkyl group, X is a substituted or unsubstituted amino, lower alkoxy, substituted phenoxy or sulfo group, Y is --SO2 CH=CH2 or --SO2 CH2 CH2 Z, in which Z is a group capable of being split by the action of an alkali, and m is 2 or 3, which is useful for dyeing hydroxyl group- or amide group-containing fiber materials to give dyed products of a brown color having excellent fastness properties with good build-up property.
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(2008/06/13)

SYNTHESIS OF (+)-(3S,7S,10S)- AND (+)-(3S,7S,10R)-3,7,10-TRIMETHYLBORATRANE. AMPLIFICATION OF ENANTIOMERIC PURITY IN THE REACTION BETWEEN AMMONIA AND PROPYLENE OXIDE
The synthesis is described of the two enantiomerically pure isomers (+)-(3S,7S,10S)- and (+)-(3S,7S,10R)-3,7,10-trimethylboratrane.The structures were determined by 1H- and 13C-NMR spectroscopy.A method for increasing the enantiomeric purity by trimerization reactions of partially-resolved (S)propylene oxide is proposed.The reaction was studied from the kinetic viewpoint and interpreted according to a binomial probability scheme.The experimental findings point to a rapid growth in enantiomeric purity for the (SSS) trimer compared with the starting material, whilst no increase was found for the (SSR) trimer.
Grassi, M.,Silvestro, G. Di,Farina, M.
p. 177 - 182
(2007/10/02)

Quaternary alkynoxymethyl amines
This invention relates to quaternaries of alkynoxymethyl amines and uses thereof. These may be summarized by the following formulae: STR1 where R and R' are substituted groups such as alkyl, aryl, etc.; R'" is an acetylenic group; and X is an anion; and STR2 where R and R'" having the same meaning as in (1) and Z is a bridging group, preferably hydrocarbon such as alkylene, alkinylene, alkenylene, arylene, etc.
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(2008/06/13)

Microbiocidal quaternaries of halogen derivatives of alkynoxymethyl amines
This invention relates to quaternaries of halogen derivatives of alkynoxymethyl amines and uses thereof. These may be summarized by the following formulae: STR1 where R and R' are substituted groups such as alkyl, aryl, etc.; R" is an alkylidene group; and X is halogen and A is an anion; and STR2 where R, R' and R" having the same meaning as in (1) and Z is a bridging group, preferably hydrocarbon such as alkylene, alkinylene, alkenylene, arylene, etc.
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(2008/06/13)

Alkynoxymethyl amines
This invention relates to alkynoxymethyl amines, to methods of preparing them, and uses thereof, particularly as corrosion inhibitors. These compounds are prepared by reacting an amine, such as RNH2, with an aldehyde, such as formaldehyde, and an alkynol, such as propargyl alcohol, to yield compounds of the formula where R is a substituted group, preferably alkyl, cycloalkyl, aryl, etc., and R' is an acetylenic alcohol moiety.
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(2008/06/13)

Halogen derivatives of alkynoxymethyl amines
This invention relates to halogen derivatives of alkynoxymethylamines and to uses thereof. The present invention may be ideally illustrated by the following equation: where R is a substituted group, preferably hydrocarbon, such as alkyl, cycloalkyl, aryl, etc., R' is hydrocarbon, preferably alkylene, and where X is halogen.
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(2008/06/13)