- A One-step Synthesis of Acridines via Palladium(II)-catalysed Ring Formation of Allylated Enaminones
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9-Ethyl-3,4,5,6,9,10-hexahydroacridine-1(2H),8(7H)-dione (5) and its N-allyl analogue (6) were formed in a one-step ring-forming reaction from both the 2-and/or N-allyl derivatives of 3-aminocyclohex-2-enone (1) - (4) and from the bisenaminone (7), obtained from the N-allylenaminone (2), on treatment with PdCl2(MeCN)2.
- Iida, Hideo,Yuasa, Yoshifumi,Kibayashi, Chihiro
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- Rapid and Scalable Access into Strained Scaffolds through Continuous Flow Photochemistry
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Two conformationally restricted three-dimensional aminoketone scaffolds have been synthesized in only three steps, using a continuous flow photochemistry approach, which is also amenable to scale-up. In addition, several approaches to further derivatize these scaffolds for the synthesis of low molecular weight compound libraries have been detailed.
- Blanco-Ania, Daniel,Gawade, Sagar Ashok,Zwinkels, Luc J. L.,Maartense, Luuk,Bolster, Marjon G.,Benningshof, Jorg C. J.,Rutjes, Floris P. J. T.
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