- PREPARATION OF α-OXYGENATED PHOSPHINE OXIDES FROM CHLORODIPHENYLPHOSPHINE
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A range of α-alkoxyphosphine oxides, including novel α-methoxyallyl oxides, are readily prepared from chlorodiphenylphosphine and acetals.
- Maleki, Mehran,Miller, Allen,Lever, O. William Jr.
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- The Synthesis of E Enol Ethers of Protected 4-Amino Aldehydes
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The title compounds, a novel class of protected homoallylic amines, have been synthesised by a short and efficient route.Acrolein acetals were converted by a modified Michaelis-Arbuzov reaction into α-alkoxyallyl(diphenyl)phosphine oxides. 1,3-Dipolar cycloaddition to the alkene part of these molecules gave 5-diphenylphosphinoyl-4,5-dihydroisoxazoles, which were reductively cleaved to obtain δ-amino-β-hydroxy-α-alkoxyalkyl(diphenyl)phosphine oxides.After selective protection as the N-acyl derivatives, stereospecific Wittig-Horner diphenylphosphinic acid elimination gave the title compounds.
- Armstrong, Susan K.,Collington, Eric W.,Warren, Stuart
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p. 515 - 520
(2007/10/02)
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- 2-Methoxy-1,3-dienes - Preparation via α-Methoxyallylphosphine Oxides using a One-pot Wittig-Horner Reaction
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2-Methoxy-1,3-dienes bearing an aryl group at position 1 and/or 4 are readily available in a one-pot Wittig-Horner reaction using α-methoxyallylphosphine oxides (1a) or (1b).
- Birse, Ewan F.,Maleki, Mehran,Miller, J. Allen,Murray, Alistair W.
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p. 864 - 872
(2007/10/02)
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