Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily
Highly proficient, promiscuous enzymes can be springboards for functional evolution, able to avoid loss of function during adaptation by their capacity to promote multiple reactions. We employ a systematic comparative study of structure, sequence, and sub
Van Loo, Bert,Bayer, Christopher D.,Fischer, Gerhard,Jonas, Stefanie,Valkov, Eugene,Mohamed, Mark F.,Vorobieva, Anastassia,Dutruel, Celine,Hyv?nen, Marko,Hollfelder, Florian
supporting information
p. 370 - 387
(2019/01/08)
Efficient catalytic promiscuity for chemically distinct reactions
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Babtie, Ann C.,Bandyopadhyay, Subhajit,Olguin, Luis F.,Hollfelder, Florian
supporting information; experimental part
p. 3692 - 3694
(2009/10/02)
Catalysis of the hydrolysis of esters of phosphorus acids by n-decylammonium chloride/n-decylamine mixed micelles
The effect of n-decylammonium chloride/n-decylamine mixed micelles on the rate of hydrolysis of aryl esters of acids of four-coordinate phosphorus was studied spectrophotometrically. The shape of the concentration curves is characteristic of the micellar
Bakeeva,Kudryavtseva,Bel'skii,Fedorov,Ivanov
p. 1900 - 1903
(2007/10/03)
Catalytic Hydrolysis of a Phosphate Triester by Tetracoordinated Zinc Complexes
A zinc complex of a tetraaza macrocycle catalyzes the hydrolysis of diphenyl p-nitrophenyl phosphate in aqueous acetonitrile.The principial products derive from loss of p-nitrophenol, but some alternative hydrolysis with loss of phenol is also observed.Ki
Gellman, Samuel H.,Petter, Russell,Breslow, Ronald